{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:11:54Z","timestamp":1776093114734,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the sensitivity and specificity of topical fluorescein sodium (FNa) to acetic acid (AA) for the detection of high\u2010grade cervical lesions\u00a0in colposcopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective, cross\u2010sectional study was conducted between January and November 2017 at Christus Muguerza Hospital Conchita in Monterrey, Mexico. 78 women between 18 and 65\u2009years age with a documented abnormal cervical smear test were included. Colposcopy by independent application of 5% AA and 0.06% topical FNa was performed and biopsy obtained for each woman.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>68 (87%) women tested positive with FNa, while 10 (13%) tested negative. Biopsy demonstrated high grade cervical lesions in 31 of the FNa positive but none of the FNa negative women. FNa staining demonstrated 100% sensitivity, 21% specificity, 46% positive predictive value (PPV), and 100% negative predictive value (NPV) to detect high\u2010grade lesions. In comparison, acetic acid staining demonstrated 100% sensitivity, 9% specificity, 42% PPV, and 100% NPV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FNa had a 133% higher diagnostic specificity than AA (21% vs. 9%) for high\u2010grade lesions at a comparable cost and convenience. Visual inspection with FNa has the potential to replace visual inspection with AA in low\u2010resource settings, thus enabling true \u201cdiagnose and treat\u201d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70481","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T23:27:42Z","timestamp":1759793262000},"page":"138-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fluorescein colposcopy\u2014A more specific diagnostic method for detection of high\u2010grade cervical precancer lesions than acetic acid"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6316-6436","authenticated-orcid":false,"given":"Sudabeh","family":"Moein","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kaiser Permanente  Santa Clara California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Arnoldo L\u00f3pez","family":"Romo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidad de Monterrey  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence B.","family":"Fischel","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering Zan Health Ltd.  Tazewell Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5409-6488","authenticated-orcid":false,"given":"Nidhi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dr. KNS Memorial Institute of Medical Sciences  Barabanki India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseline","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Research Institute UCSD School of Public Health  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Tir\u00e1n","family":"Saucedo","sequence":"additional","affiliation":[{"name":"FACOG, Department of Obstetrics and Gynecology Universidad de Monterrey  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The Immortal Life of Henrietta Lacks","author":"Skloot R","year":"2010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.97.5.695"},{"key":"e_1_2_9_4_1","volume-title":"Cervical Cancer","author":"World Health Organization","year":"2024"},{"key":"e_1_2_9_5_1","unstructured":"Cervical cancer statistics|World Cancer Research Fund. 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