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The rising global cesarean birth rate has coincided with an increase in post\u2010cesarean sepsis \u2013 specifically site infections, which have an incidence of 7% worldwide. Post\u2010cesarean sepsis remains a serious complication that prolongs hospital stays, resulting in additional surgery and worsening maternal morbidity and mortality, and increasing healthcare costs with socioeconomic consequences. There is no global practice guide for post\u2010cesarean sepsis, despite most maternal deaths due to sepsis occurring postpartum. Here we introduce a FIGO Committee on Infections During Pregnancy guide on prevention and treatment of post\u2010cesarean sepsis. We encourage strategies to keep cesarean birth rates at evidence\u2010based levels by aiming to standardize the management of labor and to increase the percentage of vaginal births after a previous cesarean. Identification of risk factors before and during the surgery is the primary step towards prevention. These measures, combined with evidence\u2010based strategies to promote infection prevention practices, including routine prophylactic antibiotics, skin and vaginal preparation before cesarean birth, and glove change prior to skin closure, contribute towards reducing maternal morbidity and mortality.<\/jats:p>","DOI":"10.1002\/ijgo.70500","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T14:19:49Z","timestamp":1757081989000},"page":"517-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reducing post\u2010cesarean sepsis: Current best practice in prevention and treatment"],"prefix":"10.1002","volume":"171","author":[{"given":"Amanda","family":"Lazzaro","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal North Shore Hospital  St. Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauri","family":"Karandikar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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