{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:45:47Z","timestamp":1790603147325,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of fractional microablative radiofrequency (RF) and topical estriol in the treatment of genitourinary syndrome of menopause (GSM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This pilot randomized controlled trial included 30 healthy postmenopausal women with GSM. Participants were randomly assigned to receive either fractional microablative RF plus placebo cream (RF group) or topical estriol plus sham RF (estriol group). Both treatments were administered over 3\u2009months. Primary outcomes included vaginal health (Vaginal Health Index Score\u2014VHIS), sexual function (Female Sexual Function Index\u2014FSFI), and urinary symptoms (International Consultation on Incontinence Questionnaire\u2014Short Form\u2014ICIQ\u2010SF). Safety was assessed through reports of adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both RF and estriol significantly improved VHIS, FSFI, and ICIQ\u2010SF scores (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Estriol provided greater improvement in sexual desire, while RF demonstrated superior results in satisfaction, dyspareunia reduction, and epithelial elasticity. No severe adverse effects occurred; mild discomfort was reported in the RF group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fractional microablative RF and topical estriol are both effective and safe for relieving GSM symptoms. RF offers a promising non\u2010hormonal alternative, especially for women who cannot or choose not to use estrogen therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70563","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:05:14Z","timestamp":1760011514000},"page":"521-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of fractional microablative radiofrequency versus topical estriol in treating genitourinary syndrome of menopause: A pilot study"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8350-5693","authenticated-orcid":false,"given":"Priscila de Almeida","family":"Torre","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-0022","authenticated-orcid":false,"given":"Susana Cristina Aid\u00e9 Viviani","family":"Fialho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Cristina Chulvis","family":"do Val Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Ximena","family":"Zunino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuani","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Alves de Oliveira","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Federal Fluminense University (UFF)  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-5119","authenticated-orcid":false,"given":"Ana K.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Rio Grande do Norte (UFRN)  Natal RN Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001609"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2024.108008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15304"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000002326"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2023.100293"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2025.01.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-075841"}],"container-title":["International Journal of Gynecology &amp; 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