{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:56:49Z","timestamp":1773035809184,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The optimal delivery approach for fetal growth restriction (FGR) with pathological cerebroplacental ratio (CPR) remains uncertain. This study evaluated the association between isolated pathological CPR (&lt;5th percentile) and delivery outcomes, specifically the rate of cesarean delivery (CD) due to non\u2010reassuring fetal heart rate (NRFHR), in FGR cases undergoing induction of labor (IOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study (2014\u20132023), pregnancies with FGR (estimated fetal weight\u2009&lt;\u200910th percentile) undergoing IOL were stratified by CPR values: pathological (&lt;5th percentile) and normal CPR. Exclusion criteria included multiple gestations, abnormal umbilical artery or ductus venosus Doppler, abnormal non\u2010stress test or biophysical profile, major fetal anomalies, and genetic disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 432 FGR, 86 had pathological CPR. This group had higher rates of second\u2010trimester human chorionic gonadotropin (HCG) &gt;2.5 multiples of the median (11.7% vs. 3.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) and delivered earlier (37.1 vs. 38.0\u2009weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Overall CD rates and CD due to NRFHR were comparable between groups (19.8% vs. 18.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.84; 14.0% vs. 15.9%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.66, respectively). Neonates with pathological CPR had lower birthweights (2174\u2009\u00b1\u2009279\u2009g vs. 2279\u2009\u00b1\u2009278\u2009g,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and higher neonatal intensive care unit (NICU) admission rates (17.4% vs. 9.2%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.03). Logistic regression analysis adjusted for potential confounders showed no independent association between pathological CPR and increased risk of CD due to NRFHR (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.74).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In FGR pregnancies undergoing IOL, isolated pathological CPR is not associated with an increased risk of cesarean delivery for NRFHR. However, these fetuses remain at higher risk for NICU admissions, emphasizing the need for individualized management and close monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70573","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:23:16Z","timestamp":1759314196000},"page":"1729-1734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is pathological fetal Doppler cerebroplacental ratio (\n                    <scp>CPR<\/scp>\n                    ) associated with adverse delivery outcomes in pregnancies complicated by fetal growth restriction undergoing labor induction? A retrospective cohort study"],"prefix":"10.1002","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7119-3442","authenticated-orcid":false,"given":"Nofar","family":"Bar Noy\u2010Traub","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Meir Medical Center  Kfar Saba Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eden","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Meir Medical Center  Kfar Saba Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaked","family":"Yarza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Meir Medical Center  Kfar Saba Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eynit","family":"Grinblatt","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Neonatology Meir Medical Center  Kfar Saba Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tal","family":"Biron\u2010Shental","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Meir Medical Center  Kfar Saba Israel"},{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Arnon","sequence":"additional","affiliation":[{"name":"Gray Faculty of Medical and Health Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Neonatology Meir Medical Center  Kfar Saba 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