{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:32:42Z","timestamp":1784208762227,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify the long\u2010term child outcomes after prenatal aspirin exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study is a follow\u2010up of a randomized controlled trial (RCT) evaluating low\u2010dose aspirin in the prevention of recurrent spontaneous preterm labor (the APRIL study) comparing aspirin 80\u2009mg daily (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009194) to placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009193) in singletons. Children were assessed at 4\u2009years corrected age using the Ages and Stages Questionnaire (third edition, ASQ\u20103) and the Strengths and Difficulties Questionnaire (SDQ) for (neuro)development and behavioral outcomes, respectively. Data on mortality, general health, growth and a composite of abnormal child outcome or mortality were also collected. Analyses were performed reporting odds ratio (OR) and 95% confidence intervals (CIs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight children were deceased until 4\u2009years follow\u2010up (all perinatal deaths;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096 in aspirin and\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092 in the placebo group). We included 231\/379 (60.9%) children: 111\/231 in the aspirin and 120\/231 in the placebo groups. Total ASQ\u20103 score was higher in the aspirin group (mean 259.3 vs. 248.3, mean difference 10.96, 95% CI: 0.17\u201321.76). The rate of children with an ASQ\u20103 score of \u22651SD below the normative data did not differ between groups (35.2% vs. 47.4%; OR 0.60, 95% CI: 0.33\u20131.09), nor did a score on the SDQ \u226580th centile (18.3% vs. 14.7%; OR 1.30, 95% CI: 0.64\u20132.66). General health, growth and the composite outcome of abnormal child development or mortality did not significantly differ between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found no harmful effects of daily prenatal exposure to aspirin 80\u2009mg. Our findings contribute to the existing data confirming the safety of low\u2010dose aspirin use in pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70581","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:05:32Z","timestamp":1761379532000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010term child outcomes after prenatal aspirin exposure: A\u00a04\u2010year follow\u2010up of a randomized controlled trial (the\n                    <scp>APRIL<\/scp>\n                    study)"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2381-0332","authenticated-orcid":false,"given":"Emilie V. 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