{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:12:50Z","timestamp":1776093170409,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study compares the effectiveness and safety of three prophylactic uterotonic regimens\u2014intravenous carbetocin, oxytocin infusion, and oxytocin\u2013ergometrine combination\u2014in preventing postpartum hemorrhage (PPH) in women with isolated polyhydramnios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cohort study included 286 term pregnancies complicated by isolated polyhydramnios, managed at a tertiary obstetric center between January 2020 and April 2024. Participants received a single prophylactic uterotonic immediately after placental delivery: carbetocin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009124), oxytocin (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009116), or oxytocin\u2013ergometrine (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946). Patients with additional PPH risk factors were excluded. Primary outcomes included hemoglobin and hematocrit changes, estimated blood loss, and 6\u2010h postpartum shock index. Secondary outcomes were rates of transfusion, surgical intervention, and uterine\u2010sparing procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Carbetocin was associated with significantly smaller drops in hemoglobin and hematocrit, lower estimated blood loss, and more favorable shock index values compared to the other groups. These advantages were consistent across cesarean, primiparous, and multiparous vaginal deliveries. Although not statistically significant, fewer secondary interventions (e.g., transfusion, balloon tamponade, and compression sutures) were recorded in the carbetocin group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among women with isolated polyhydramnios, carbetocin offers superior prophylactic control of PPH compared to oxytocin and oxytocin\u2013ergometrine regimens. Its long\u2010acting effect provides sustained uterine contraction, reducing the need for additional interventions. Carbetocin might be especially beneficial in high\u2010risk cases of uterine overdistension, supporting its targeted use in individualized obstetric care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70585","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:21:52Z","timestamp":1760404912000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One dose, big impact: Revisiting carbetocin in high\u2010risk polyhydramnios deliveries"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-4364","authenticated-orcid":false,"given":"Burak","family":"Elmas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ac\u0131badem Maslak Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-0812","authenticated-orcid":false,"given":"U\u011furcan","family":"Zorlu","sequence":"additional","affiliation":[{"name":"Department of Perinatalogy Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1064-8727","authenticated-orcid":false,"given":"Gonca","family":"T\u00fcrker Erg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-181X","authenticated-orcid":false,"given":"Batuhan","family":"Turgay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-8612","authenticated-orcid":false,"given":"Bur\u00e7in","family":"Salman\u2010\u00d6zg\u00fc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3083-6203","authenticated-orcid":false,"given":"\u00c7i\u011fdem","family":"Karag\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3718-136X","authenticated-orcid":false,"given":"Beng\u00fc Nur","family":"Bar\u0131\u015f Akcan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Mamak State Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4901-1849","authenticated-orcid":false,"given":"G\u00fcl","family":"Kurtaran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-3837","authenticated-orcid":false,"given":"\u00d6zlem","family":"Moralo\u011flu Tekin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Van Der NelsonHA.Prophylactic Uterotonic Drugs for Prevention of Postpartum Haemorrhage after Vaginal Birth [dissertation]. University of Bristol; 2022."},{"key":"e_1_2_13_3_1","unstructured":"AflaifelN.Postpartum haemorrhage: new insights from published trials and the development of novel management options.2015Accessed Apr 12 2025."},{"key":"e_1_2_13_4_1","volume-title":"A Textbook of Postpartum Hemorrhage","author":"Unterscheider J","year":"2012"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001765"},{"key":"e_1_2_13_6_1","first-page":"495","article-title":"Comparison of two intravenous oxytocin regimens for prevention of postpartum hemorrhage during cesarean delivery: a randomized controlled trial","volume":"12","author":"Yaliwal RG","year":"2020","journal-title":"Int J Women's Health"},{"key":"e_1_2_13_7_1","unstructured":"Thiong'oJW.A study to determine the prevalence of postpartum hemorrhage among mothers with high\u2010risk pregnancies including polyhydramnios.2014Accessed Apr 12 2025."},{"issue":"2","key":"e_1_2_13_8_1","first-page":"35","article-title":"Uterotonic drugs in the prevention of postpartum hemorrhages","volume":"1","author":"Khamidullina ZG","year":"2020","journal-title":"Reprod Health Obstet"},{"issue":"3","key":"e_1_2_13_9_1","first-page":"145","article-title":"Intravenous administration of carbetocin versus oxytocin for preventing postpartum hemorrhage after vaginal delivery in high\u2010risk women: a randomized controlled trial","volume":"2","author":"Liu H","year":"2020","journal-title":"Matern Fetal Med"},{"issue":"8","key":"e_1_2_13_10_1","first-page":"557","article-title":"A standardized postpartum oxytocin protocol to reduce hemorrhage treatment: outcomes by delivery mode","volume":"45","author":"Seagraves E","year":"2019","journal-title":"Jt Comm J Qual Patient Saf"},{"issue":"2","key":"e_1_2_13_11_1","first-page":"212","article-title":"Transvaginal surgical treatment of early postpartum hemorrhage caused by lower uterine segment atony","volume":"50","author":"Habek D","year":"2022","journal-title":"J Perinat Med"},{"issue":"11","key":"e_1_2_13_12_1","first-page":"1801","article-title":"Oxytocin versus Syntometrine\u00ae versus Carbetocin for prevention of primary postpartum hemorrhage after vaginal birth: a randomised double\u2010blinded clinical trial","volume":"128","author":"Van Der Nelson H","year":"2021","journal-title":"BJOG"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.7881"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.04.002"},{"issue":"2","key":"e_1_2_13_15_1","first-page":"113","article-title":"Efficacy of carbetocin versus oxytocin and ergometrine in prevention of PPH after cesarean section","volume":"7","author":"Esseissah SA","year":"2022","journal-title":"Benha J Appl Sci"},{"issue":"2","key":"e_1_2_13_16_1","first-page":"138","article-title":"Carbetocin versus oxytocin for prevention of PPH in patients with severe preeclampsia: a double\u2010blind RCT","volume":"33","author":"Reyes OA","year":"2011","journal-title":"J Obstet Gynaecol Can"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02585.x"},{"issue":"9","key":"e_1_2_13_18_1","first-page":"2225","article-title":"Effectiveness and safety of carbetocin versus oxytocin: a systematic review and meta\u2010analysis","volume":"48","author":"Sun H","year":"2022","journal-title":"J Obstet Gynaecol Res"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3109-2"},{"issue":"10","key":"e_1_2_13_20_1","first-page":"1601","article-title":"Efficacy of carbetocin in prevention of PPH: a systematic review and Bayesian meta\u2010analysis","volume":"34","author":"Kalafat E","year":"2021","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"3","key":"e_1_2_13_21_1","first-page":"145","article-title":"Carbetocin vs oxytocin for preventing PPH after vaginal delivery in high\u2010risk women: a double\u2010blind RCT","volume":"2","author":"Liu H","year":"2020","journal-title":"Matern Fetal Med"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0279130"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-023-09263-4"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0003562"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.745"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1374150"}],"container-title":["International Journal of Gynecology &amp; 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