{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:36:42Z","timestamp":1794278202797,"version":"4.9.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Assess high\u2010risk human papillomavirus (HPV) prevalence and high\u2010grade squamous intraepithelial lesion\/cervical intraepithelial neoplasia (HSIL\/CIN) grade 2+ detection by cervical biopsy and endocervical curettage (ECC) in women younger than 30\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed medical records from January 2016 to June 2024 at a tertiary hospital. All women aged 21\u2009years and older who underwent HPV and Papanicolaou testing, plus those younger than 30\u2009years referred for colposcopy, were included. Data on age, HPV status, cytology, colposcopy\u2010directed biopsy, and ECC findings were extracted. The primary outcome was HSIL\/CIN 2+ incidence on pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 57\u2009381 women, high\u2010risk HPV prevalence was 14.3% overall: 36.8% in those aged 21\u201324\u2009years, 24.0% in those aged 25\u201329\u2009years, and 12.7% in those 30\u2009years and older. Of 735 women younger than 30\u2009years, 291 were managed by follow\u2010up decision and 444 underwent biopsy\/ECC; follow\u2010up decision was more common in women aged 21\u201324\u2009years versus those 25\u201329\u2009years (49% vs. 35.8%). Among the 444 women who underwent biopsy, HSIL\/CIN 2+ and HSIL\/CIN 3+ occurred in 37.8% and 14.6%, respectively, with similar HSIL\/CIN 3+ rates in those aged 21\u201324\u2009years versus those 25\u201329\u2009years (16.8% vs. 13.9%). In 173 women with benign cytology, 30.1% had HSIL\/CIN 2+ on pathology. The number needed to screen for HSIL was approximately 2\u20133 after co\u2010testing versus approximately 40 with Papanicolaou testing alone. In addition, Papanicolaou test alone demonstrated poor agreement with biopsy\/ECC results (low Cohen\n                      <jats:italic>\u03ba<\/jats:italic>\n                      ), confirming its inadequate performance. Two cases of cervical cancers were diagnosed at ages 22 and 29\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Similar high\u2010grade lesion rates in women aged 21\u201324\u2009years and those 25\u201329\u2009years support initiating cervical cancer screening at age 21\u2009years. Given the substantial HSIL detection despite benign cytology, co\u2010testing with Papanicolaou and HPV testing is recommended in this age group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70588","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:02:58Z","timestamp":1760378578000},"page":"209-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Human papillomavirus positivity and cervical intraepithelial lesion in cervical biopsy and endocervical curettage in women younger than 30\u2009years"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0895-0935","authenticated-orcid":false,"given":"\u0130brahim","family":"G\u00fclhan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"\u00d6r\u00fcn","sequence":"additional","affiliation":[{"name":"\u015e\u0131rnak Community Health Directorate Republic of T\u00fcrkiye Ministry of Health  \u015e\u0131rnak T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fen","family":"Yan\u0131\u011fl\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumeysa Nur","family":"\u00c7a\u011f\u0131ran","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman Hamdi","family":"\u0130nan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korkut","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Medical Pathology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunus Emre","family":"Purut","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"G\u00f6k\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medicalpoint Hospital Department of Obstetrics and Gynecology \u0130zmir University of Economics  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"\u00d6zeren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology \u0130zmir Tepecik Training and Research Hospital  \u0130zmir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization (WHO).Existence of national HPV vaccination programme in the national immunization schedule.2025Accessed April 12 2025.https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator\u2010details\/GHO\/existence\u2010of\u2010national\u2010hpv\u2010vaccination\u2010programme"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.10897"},{"key":"e_1_2_9_5_1","volume-title":"WHO Guideline for Screening and Treatment of Cervical Pre\u2010Cancer Lesions for Cervical Cancer Prevention","author":"World Health Organization (WHO)","year":"2021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21628"},{"key":"e_1_2_9_7_1","unstructured":"The American College of Obstetricians and Gynecologists (ACOG).Updated Cervical Cancer Screening Guidelines.2024Accessed April 12 2025.https:\/\/www.acog.org\/clinical\/clinical\u2010guidance\/practice\u2010advisory\/articles\/2021\/04\/updated\u2010cervical\u2010cancer\u2010screening\u2010guidelines"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31825c31dd"},{"key":"e_1_2_9_9_1","volume-title":"Global Strategy to Accelerate the Elimination of Cervical Cancer as a Public Health Problem","author":"World Health Organization 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