{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:11:52Z","timestamp":1776093112294,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the financial applicability of the DNA\u2010HPV test for cervical cancer screening in a developing country like Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective, observational study based on documentary data, conducted to assess the cost\u2010effectiveness of cervical cancer screening strategies in Brazil. The study used national cervical cancer screening data collected between January 1 and December 31, 2020 for women between 25 and 64\u2009years old, performing a cost\u2010effectiveness assessment of two different screening tests. No sensitivity analysis was conducted due to the descriptive nature of this preliminary cost assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Based on the cervical smear, the Brazilian protocol has an estimated cost of US$117.5 million. In contrast, when using the HPV DNA test, the estimated cost is US$1.39 billion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current use of the cervical smear is the least expensive and the only one that aligns with Brazil's financial resources allocated to health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70594","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:10:52Z","timestamp":1760447452000},"page":"157-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Introduction of\n                    <scp>DNA<\/scp>\n                    \u2010\n                    <scp>HPV<\/scp>\n                    test in the Brazilian cervical cancer screening program: When the idea is good but does not fit the budget"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2020-2980","authenticated-orcid":false,"given":"Felipe Polido","family":"Urbano","sequence":"first","affiliation":[{"name":"Pathology Department, Medical School Salesian Catholic University Center Auxilium (UNISALESIANO)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-716X","authenticated-orcid":false,"given":"Gabriel Russo","family":"Cury","sequence":"additional","affiliation":[{"name":"Pathology Department, Medical School Salesian Catholic University Center Auxilium (UNISALESIANO)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5593-1062","authenticated-orcid":false,"given":"Caio Rodrigo","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Pathology Department, Medical School Salesian Catholic University Center Auxilium (UNISALESIANO)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-8589","authenticated-orcid":false,"given":"Daniel Jos\u00e9 Castilho","family":"da Silva","sequence":"additional","affiliation":[{"name":"Pathology Department, Medical School Salesian Catholic University Center Auxilium (UNISALESIANO)  Ara\u00e7atuba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-419X","authenticated-orcid":false,"given":"Jos\u00e9 C\u00e2ndido Caldeira","family":"Xavier\u2010J\u00fanior","sequence":"additional","affiliation":[{"name":"Pathology Department, Medical School Salesian Catholic University Center Auxilium (UNISALESIANO)  Ara\u00e7atuba S\u00e3o Paulo Brazil"},{"name":"Pathology Department Institute of Ara\u00e7atuba  Ara\u00e7atuba S\u00e3o Paulo Brazil"},{"name":"Pathology Department S\u00e3o Paulo State University, UNESP  Botucatu S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_1","volume-title":"WHO.int. WHO Guideline for Screening and Treatment of Cervical Pre\u2010Cancer Lesions for Cervical Cancer Prevention","author":"World Health Organization","year":"2021"},{"key":"e_1_2_11_4_1","unstructured":"Minist\u00e9rio da Sa\u00fade Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva Minist\u00e9rio da Sa\u00fade Instituto Nacional de C\u00e2ncer.Estimativa 2023. Incid\u00eancia de C\u00e2ncer no Brasil.2022.https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/\/media\/document\/\/estimativa\u20102023.pdf"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.5123\/s1679-49742018000200003"},{"key":"e_1_2_11_6_1","unstructured":"Instituto Nacional de C\u00e2ncer (INCA). Minist\u00e9rio da Sa\u00fade. Coordena\u00e7\u00e3o de Preven\u00e7\u00e3o e Vigil\u00e2ncia. Divis\u00e3o de Detec\u00e7\u00e3o Precoce e Apoio \u00e0 Organiza\u00e7\u00e3o de Rede.DADOS E N\u00fameros SOBRE C\u00e2ncer Do Colo Do \u00datero \u2010 Relat\u00f3rio Anual 2022.https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/media\/document\/dados_e_numeros_colo_22setembro2022.pdf"},{"key":"e_1_2_11_7_1","unstructured":"Brazilian guidelines for cervical cancer screening. Instituto Nacional de C\u00e2ncer \u201cJos\u00e9 Alencar Gomes da Silva\u201d Divis\u00e3o de Detec\u00e7\u00e3o Precoce e Apoio \u00e0 Organiza\u00e7\u00e3o de Rede 2\u00b0 edi\u00e7\u00e3o vers\u00e3o 2016.https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/media\/document\/diretrizesparaorastreamentodocancerdocolodoutero_2016_corrigido.pdf"},{"key":"e_1_2_11_8_1","first-page":"238","article-title":"Rastreamento do c\u00e2ncer do colo do \u00fatero: do exame de Papanicolau \u00e0s estrat\u00e9gias futuras","volume":"52","author":"Mitteldorf CATS","year":"2016","journal-title":"Jornal Brasileiro de Patologia e Medicina Laboratorial"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.08.394"},{"key":"e_1_2_11_10_1","volume-title":"Control of Cervical and Breast Cancers","author":"Announcing the Health Care Department and the Primary Care Department","year":"2013"},{"key":"e_1_2_11_11_1","unstructured":"Source Gandra A.Misinformation is a Major Obstacle to Cervical Cancer Control.2022.https:\/\/agenciabrasil.ebc.com.br\/saude\/noticia\/2022\u201002\/desinformacao\u2010e\u2010maior\u2010entrave\u2010para\u2010controle\u2010do\u2010cancer\u2010do\u2010colo\u2010do\u2010utero#:~:text=A%20imuniza%C3%A7%C3%A3o%20contra%20o%20HPV vacinal%20foi%2036%2C4%25"},{"key":"e_1_2_11_12_1","unstructured":"Cancer Information System \u2013 SISCAN (cervix and breast) \u2013 DATASUS. Saude.gov.br.2022.https:\/\/datasus.saude.gov.br\/acesso\u2010a\u2010informacao\/sistema\u2010de\u2010informacao\u2010do\u2010cancer\u2010siscan\u2010colo\u2010do\u2010utero\u2010e\u2010mama\/"},{"key":"e_1_2_11_13_1","first-page":"479","article-title":"Excessive pap smears due to opportunistic cervical cancer screening","volume":"29","author":"Freitas RA","year":"2008","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_11_14_1","unstructured":"Brazilian Institute of Geography and Statistics (IBGE)\/Research Directorate.Projection of the Population of Brazil and Federation Units by Sex and Age for the Period 2000\u20102030: Population Coordination and Social Indicators. Management of Studies and Analysis of Demographic Dynamics.2020.https:\/\/datasus.saude.gov.br\/populacao\u2010residente\/"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528964"},{"key":"e_1_2_11_16_1","unstructured":"SIGTAP \u2010 SUS Procedures Medicines and OPM Table Management System. Datasus.gov.br.2022.http:\/\/sigtap.datasus.gov.br\/tabela\u2010unificada\/app\/sec\/inicio.jsp"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251688"},{"key":"e_1_2_11_18_1","unstructured":"Sistema de Informa\u00e7\u00e3o do C\u00e2ncer \u2013 SISCAN (colo do \u00fatero e mama) \u2013 DATASUS. Saude.gov.br.2024.https:\/\/datasus.saude.gov.br\/acesso\u2010a\u2010informacao\/sistema\u2010de\u2010informacao\u2010do\u2010cancer\u2010siscan\u2010colo\u2010do\u2010utero\u2010e\u2010mama\/"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-73312006000100007"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-19-0306"},{"key":"e_1_2_11_21_1","unstructured":"Brazilian Guidelines for Screening Cervical Cancer in Brazil Executive Summary for Primary Care. Instituto Nacional de C\u00e2ncer \u201cJos\u00e9 Alencar Gomes da Silva\u201d.2018.https:\/\/www.inca.gov.br\/sites\/ufu.sti.inca.local\/files\/\/media\/document\/\/sumario_executivo_em_portugues_\u2010_ccu.pdf"},{"key":"e_1_2_11_22_1","unstructured":"Nacional De C\u00e2ncer I Gomes Da SilvaJ.Laborat\u00f3rio de Citopatologia Minist\u00e9rio Da Sa\u00fade.https:\/\/www.citologiaclinica.org.br\/site\/pdf\/documentos\/manual_gestao_qualidade_laboratorio_citopatologia.pdf"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.02.008"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528931"},{"key":"e_1_2_11_25_1","unstructured":"Minist\u00e9rio da Sa\u00fade \u2013 Comiss\u00e3o Nacional de Incorpora\u00e7\u00e3o de Tecnologias no Sistema \u00danico de Sa\u00fade \u2013 CONITEC.Testagem Molecular para Detec\u00e7\u00e3o de HPV e Rastreamento do C\u00e2ncer do Colo do \u00datero. Relat\u00f3rio de recomenda\u00e7\u00e3o 878 2024.https:\/\/www.gov.br\/conitec\/pt\u2010br\/midias\/relatorios\/2024\/testagem\u2010molecular\u2010para\u2010deteccao\u2010de\u2010hpv\u2010e\u2010rastreamento\u2010do\u2010cancer\u2010do\u2010colo\u2010do\u2010utero\/view"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1006038"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:24:02Z","timestamp":1776090242000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/ijgo.70594"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70594","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}