{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T09:39:00Z","timestamp":1776764340845,"version":"3.51.2"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the contribution of selected methodological factors to the heterogeneity in published umbilical artery pulsatility index (UA\u2010PI) reference charts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional study of uncomplicated singleton pregnancies that underwent assessment of UA Doppler at a single center. We explored the effects of the cohort characteristics (parity and estimated fetal weight [EFW] centile cut\u2010off) and the statistical modeling approach used to construct the UA\u2010PI centile reference charts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      25\u2009069 UA\u2010PI measurements from 12\u2009394 patients were analyzed. UA\u2010PI centile values decreased as the minimal EFW centile inclusion cut\u2010off of the study cohort increased. Interpretation of UA\u2010PI using charts constructed from fetuses with EFW\u2009&gt;\u200925th or 50th centiles resulted in a higher proportion of examinations with UA\u2010PI\u2009&gt;\u200995th centile compared with the chart based on fetuses with EFW\u27e910th centile (11.5% and 13.2% versus 10.6% of the subgroup of small\u2010for\u2010gestational\u2010age fetuses, respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In contrast, parity and the statistical method used to construct the chart had minimal impact on the UA\u2010PI centile reference charts. Considerable heterogeneity was identified among published UA\u2010PI reference charts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Variation in the distribution of EFW centiles across the populations used to construct the UA\u2010PI reference chart may contribute to the heterogeneity observed in published charts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70597","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:51:14Z","timestamp":1760698274000},"page":"227-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors affecting the umbilical artery Doppler reference values in the second and third 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