{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:43Z","timestamp":1786977943884,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to analyze prenatal diagnostic indications, methods, and prognosis of fetuses with mosaicism, providing a reference for related prenatal diagnosis and genetic counseling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Cases of fetuses prenatally diagnosed with mosaicism via amniocentesis at our center over a 3\u2010year period were retrospectively reviewed. The review covered maternal age, prenatal ultrasound phenotypes, results of whole\u2010genome non\u2010invasive prenatal testing (wgNIPT), and outcomes of prenatal diagnosis, including karyotype analysis, chromosomal microarray (CMA), and fluorescence in\u00a0situ hybridization (FISH). Pregnancy outcomes and postnatal phenotypes were also examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 37 cases reviewed, 43% (16\/37) involved women of advanced maternal age (\u226535\u2009years), while 22% (8\/37) exhibited ultrasound abnormalities. Of the subset of 31 cases that underwent wgNIPT prior to amniocentesis, 94% (29\/31) had results concordant with prenatal diagnostic findings. A total of 35 cases were analyzed using multiple techniques, with 17 showing consistent findings, 10 discrepancies in mosaic or non\u2010mosaic status, and 8 conflicting results across methods. Thirteen cases resulted in live births with no apparent abnormalities detected in follow\u2010ups at ages 3\u20135.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>wgNIPT is a valuable tool for prenatal mosaicism screening, although its detection of complex cases remains limited. Prenatal diagnosis of mosaicism requires the mutual verification of multiple genetic techniques. Postnatally, mosaicism might lack apparent phenotypes; prolonged monitoring is needed to detect delayed effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70640","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T07:00:01Z","timestamp":1762326001000},"page":"386-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of cases with prenatal diagnosis of mosaicism: Indications, methods of prenatal diagnosis, and pregnancy outcome follow\u2010up"],"prefix":"10.1002","volume":"173","author":[{"given":"Qianzhu","family":"Jiang","sequence":"first","affiliation":[{"name":"Genetic Metabolism Medical Center Dalian Women and Children's Medical Center (Group)  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Dalian Municipal Central Hospital Postgraduate Training 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