{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:30:58Z","timestamp":1792805458739,"version":"4.5.0"},"reference-count":88,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of iron deficiency with anemia and iron deficiency without anemia (IDWA) during pregnancy have not been summarized, and evidence of the direct association of IDWA with adverse perinatal outcomes (APO) are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To summarize the prevalence of iron deficiency with and without anemia in pregnancy and determine if there is reported evidence of an effect for IDWA on adverse perinatal outcomes (APO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>Literature search was completed using four electronic databases, with no restrictions on date or language.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria<\/jats:title>\n                    <jats:p>Selected were observational studies, randomized controlled trials (RCTs), systematic reviews, meta\u2010analyses, narrative reviews on iron deficiency (ID) in pregnancy, published from inception to May 30, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Collection and Analysis<\/jats:title>\n                    <jats:p>Two independent reviewers screened article titles, abstracts, and full texts. The PRISMA guideline for scoping reviews was followed. A narrative summary was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 33 studies were included comprising five RCTs, 27 observational studies, and one narrative summary, involving 84\u2009618 pregnant women. The prevalence of ID varied from 1.2%\u201371.0%; 1.2%\u201355.6% (IDA), and 1.6%\u201371.0% (IDWA). Two studies exclusively reported on IDWA and APO. The first study reported on preterm birth (adjusted odds ratio [aOR] 0.9, 95% confidence interval [CI]: 0.6\u20131.4), stillbirth (aOR 4.0, 95% CI: 1.0\u201314.3), low birthweight (aOR 0.6, 95% CI: 0.4\u20131.0), and small for gestational age (aOR 0.8, 95% CI: 0.5\u20131.2) in IDWA versus iron replete. The second study reported an adjusted birthweight of 3140\u2009g (95% CI: 3067\u20133213) in IDWA and 3202\u2009g (95% CI: 3164\u20133240) in iron replete individuals (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.16).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalence of ID varied widely, with substantial variability in biomarkers and diagnostic cut\u2010offs used in case definition. There were limited studies reporting on IDWA and its association with APO. Further research is needed to establish an association and to inform early screening and determine whether treating IDWA improves perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70651","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:22:39Z","timestamp":1766575359000},"page":"1183-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Iron deficiency with and without anemia in pregnancy: A\u00a0scoping review of prevalence and perinatal impact"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5350-7441","authenticated-orcid":false,"given":"Lucky O.","family":"Lawani","sequence":"first","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0621-0637","authenticated-orcid":false,"given":"David M.","family":"Naimark","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine, Division of Nephrology Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-4658","authenticated-orcid":false,"given":"Joel G.","family":"Ray","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medicine St Michael's Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-0460","authenticated-orcid":false,"given":"Jessica","family":"Widdifield","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Department of Evaluative Clinical Sciences Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-8676","authenticated-orcid":false,"given":"Paul","family":"Eze","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Administration Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidumebi J.","family":"Idemili","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-6256","authenticated-orcid":false,"given":"Nadine","family":"Shehata","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health University of Toronto  Toronto Ontario Canada"},{"name":"Departments of Medicine, Laboratory Medicine and Pathobiology, Division of Hematology Mount Sinai Hospital, University Health Network, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13870"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0560"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16221"},{"key":"e_1_2_10_5_1","volume-title":"Nutritional Anaemias: Tools for Effective Prevention and Control","author":"World Health Organization","year":"2017"},{"key":"e_1_2_10_6_1","volume-title":"Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. 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