{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:47:18Z","timestamp":1777870038016,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To describe the limitations of sonographic estimation of fetal weight (EFW) percentiles during the second trimester; compare the accuracy of EFW percentiles to that of single fetal biometric indice; and identify the gestational age threshold beyond which the sonographic diagnosis of fetal growth restriction (FGR) becomes more reliable.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We described the limitations of EFW by simulation using the 1991 Hadlock. Then, we illustrated these limitations using data from a cohort of singleton pregnancies at a single tertiary center (2014\u20132023). The primary predictor was EFW percentile, and the primary outcome was birth weight <10th percentile for gestational age. The diagnostic accuracy was described using the area under the receiver\u2010operator characteristic curve, detection rate, false positive rate, and positive and negative predictive values.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Less than 25\u2009weeks of gestation, EFW percentiles are highly sensitive to minor dating or sonographic measurement errors. Abdominal circumference (AC) percentile is less sensitive to these errors and may be a more reliable measure. Using a cohort of 29\u2009608 patients (76\u2009378 ultrasound examinations), we confirmed that the positive predictive value (PPV) of EFW percentile for birth weight <10th percentile decline sharply before 25\u2009weeks of gestation. In addition, before 25\u2009weeks of gestation, AC <10th percentile has a higher PPV for birth weight <10th percentile than EFW <10th percentile (45% vs. 41% at 15\n 0\/7<\/jats:sup>\n \u201319\n 6\/7<\/jats:sup>\n weeks, and 61% vs. 56% at 20\n 0\/7<\/jats:sup>\n \u201324\n 6\/7<\/jats:sup>\n weeks).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Sonographic EFW percentiles are less reliable before 25\u2009weeks than later in pregnancy, and should be interpreted with caution during this gestational age period.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.70693","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:13:53Z","timestamp":1764069233000},"page":"930-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sonographic fetal weight estimation percentiles should be interpreted with caution in the second trimester"],"prefix":"10.1002","volume":"173","author":[{"given":"Ben","family":"Melamed","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Center University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elad","family":"Mei\u2010Dan","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, North York General Hospital University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2741-3679","authenticated-orcid":false,"given":"Amir","family":"Aviram","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook Health Sciences Center University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22134"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003070"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61490-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002220"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.032"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17347"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22000"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70283-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1087498"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.16018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.138.5.871"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.139.2.367"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.140.1.7244221"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.152.2.6739822"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2019.04.010"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"}],"container-title":["International Journal of Gynecology & Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70693","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:13:54Z","timestamp":1777562034000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ijgo.70693"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70693","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}