{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:26:27Z","timestamp":1793287587072,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the clinicopathologic characteristics and prognostic outcomes of patients with neuroendocrine cervical carcinoma (NECC) who underwent surgical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective descriptive analysis was conducted on 22 patients with histologically confirmed NECC who underwent surgery at the Cancer Hospital of Shantou University Medical College (2012\u20132022).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age at diagnosis was 46\u2009years. Preoperative cervical biopsies confirmed NECC in 10 cases, while 12 cases were identified as other pathologic types. Among the nine patients who underwent ThinPrep cytologic testing (TCT), seven (77.8%) exhibited abnormalities. HPV testing revealed HPV18 positivity in seven of eight diagnostic patients and HPV16 positivity in one. Lymph node metastases were detected in seven patients through lymphadenectomy. Postoperative pathology revealed concurrent malignancies in seven patients, including cervical adenocarcinoma (3), cervical adenosquamous carcinoma (1), endometrial adenocarcinoma (2), and endometrial adenosquamous carcinoma (1). Tumors expressed synaptophysin (SYN) (18\/18 cases; 100%), chromogranin (CGA) (11\/12 cases; 91.7%), and CD56 (15\/17; 88.2%). The 2\u2010year recurrence\u2010free survival (RFS) and overall survival (OS) rates were 63.6% and 68.2%, respectively; the 3\u2010year RFS and OS rates were 61.9% and 66.7%. Univariate analysis identified FIGO stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and multiple lymph node metastases (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) as significant prognostic factors for progression\u2010free survival (PFS), while multiple lymph node metastases were also significantly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) associated with OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NECC is a highly aggressive subtype of cervical cancer, frequently associated with HPV infection\u2014particularly HPV18\u2014and characterized by a high risk of lymph node metastasis and poor prognosis. NECC often coexists with other malignancies. ThinPrep cytology test (TCT) combined with HPV testing may be a potential method for early detection. Surgical resection followed by adjuvant chemotherapy and\/or radiotherapy may be an effective treatment strategy for early\u2010stage NECC. FIGO stage and the extent of multiple lymph node metastases are key prognostic factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70697","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T07:00:42Z","timestamp":1764313242000},"page":"956-962","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathologic characteristics and prognostic outcomes of surgically treated neuroendocrine cervical carcinoma: A single institution retrospective analysis"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6193-7838","authenticated-orcid":false,"given":"Anna","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology The Cancer Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4447-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004708"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2021-002587"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1743422"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-021-02017-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-023-2722-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08797-2"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2017.12.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S460465"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72055-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325803"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200107000-00016"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.207139"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23940"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-223127"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227155"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1996.tb03648.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31824735a5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.04.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm465"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2019-000504"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2019.09.018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2020.02.004"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:13:44Z","timestamp":1777562024000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ijgo.70697"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70697","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}