{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:47:21Z","timestamp":1777870041245,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate serum magnesium concentrations in pregnant women with severe pre\u2010eclampsia being treated with a novel magnesium sulfate regimen for seizure prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective, longitudinal study. Pregnant women aged 18\u2009years or older with severe pre\u2010eclampsia and an indication for treatment with magnesium sulfate were included. Participants received a magnesium sulfate loading dose of 4.5\u2009g over 20\u2009min, then a maintenance dose of 1.5\u2009g\/h (the standard regimen at the study center). Serum magnesium concentrations were measured at admission, 30\u2009min, 1, 2, 4, and 6\u2009h, then every 6\u2009h until treatment was stopped. Median (interquartile range [IQR]) serum magnesium concentrations are reported. The primary outcome was serum magnesium concentrations during magnesium sulfate infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum magnesium concentrations at admission and after 30\u2009min were 0.77 (IQR 0.72\u20130.82) and 1.81 (IQR 1.63\u20131.97) mmol\/L, respectively. After 4\u2009h, the concentration had decreased slightly to 1.79 (IQR 1.58\u20132.02) mmol\/L. By 12\u2009h, magnesium levels had stabilized at 2\u2009mmol\/L. At this time, 50.9% (28\/55) had achieved therapeutic magnesium levels (2.0\u20133.5\u2009mmol\/L), and this proportion had increased to 61.7% (29\/47) by 24\u2009h. Magnesium toxicity was observed in three patients (4.7%). No cases of eclampsia or maternal mortality were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This magnesium sulfate regimen was generally well tolerated and also prevented seizures even though serum magnesium levels at 24\u2009h were below the currently defined therapeutic range in at least one\u2010third of participants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70707","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T10:38:03Z","timestamp":1764758283000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alternative dosing regimen of magnesium sulfate for prevention of eclampsia: An observational prospective study"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5388-1425","authenticated-orcid":false,"given":"Anh M.","family":"To","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology My Duc Hospital  Ho Chi Minh City Vietnam"},{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-0082","authenticated-orcid":false,"given":"Minh H. N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-0414","authenticated-orcid":false,"given":"Tri C.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4961-6602","authenticated-orcid":false,"given":"Trung Q.","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology My Duc Hospital  Ho Chi Minh City Vietnam"},{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8072-3151","authenticated-orcid":false,"given":"Yen T. H.","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology My Duc Hospital  Ho Chi Minh City Vietnam"},{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-1042","authenticated-orcid":false,"given":"Thanh V.","family":"Le","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"},{"name":"Department of Obstetrics and Gynecology My Duc Phu Nhuan Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9332-9574","authenticated-orcid":false,"given":"Thao V.","family":"Ngo","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"},{"name":"Department of Obstetrics and Gynecology My Duc Phu Nhuan Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7267-2274","authenticated-orcid":false,"given":"Toan D.","family":"Pham","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3528-7358","authenticated-orcid":false,"given":"Tuong M.","family":"Ho","sequence":"additional","affiliation":[{"name":"HOPE Research Center My Duc Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6529-6912","authenticated-orcid":false,"given":"Lan N.","family":"Vuong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2025.1533843"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_10_5_1","article-title":"Alternative magnesium sulphate regimens for women with pre\u2010eclampsia and eclampsia","volume":"10","author":"Diaz V","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","article-title":"Magnesium sulphate and other anticonvulsants for women with pre\u2010eclampsia","volume":"3","author":"Duley L","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_7_1","article-title":"Magnesium sulphate versus phenytoin for eclampsia","volume":"10","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_8_1","article-title":"Magnesium sulphate versus diazepam for eclampsia","volume":"12","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_9_1","article-title":"Magnesium sulphate versus lytic cocktail for eclampsia","volume":"9","author":"Duley L","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113670"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101765"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00561"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.25077\/aoj.9.1.1-15.2025"},{"issue":"8","key":"e_1_2_10_14_1","article-title":"Efficacy of magnesium sulfate on maternal mortality in eclampsia","volume":"13","author":"Padda J","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_10_15_1","unstructured":"World Health Organization.WHO recommendations for prevention and treatment of pre\u2010eclampsia and eclampsia.2011. 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