{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:47:02Z","timestamp":1777870022650,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate temporal trends of Neonatal Diseases(NDs) and their subtypes in China from 1990 to 2021, as well as risk factors of NDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the global Burden of Disease 2021 data, NDs and four subtypes were evaluated through case numbers, disability\u2010adjusted life years (DALYs), age\u2010standardized prevalence (ASPR), mortality (ASMR), and Joinpoint analysis: The burden of premature birth (NPB), encephalopathy caused by asphyxia and birth injury (NE), neonatal sepsis and other infections (NS), hemolytic diseases and other jaundice (HD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In 2021, the prevalence number and mortality number of NDs in China\u2019s total population were 13, 173, 461 cases and 27,546 cases , ASPR and ASMR were 1034.89\/100,000 respectively (95%UI:986.86, 1093.58) and 5.13\/100,000 (95%UI:4.39, 6.08), increased and decreased by 1.68% and 81.08% respectively. For specific types of NDs, the burden of NPB decreased, NE and HD increased, while NS showed an \u201cM\u201d\u2010shaped trend. The burden of death of four types of NDs decreased. The burden of death and DALYs caused by four risk factors decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In China, prevalence burden of NDs has increased, while mortality has declined. These findings provide a scientific basis for targeted prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70709","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:37:27Z","timestamp":1764844647000},"page":"1075-1086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease burden and risk factors of neonatal disorders in China from 1990 to 2021: An analysis of the global burden of disease study 2021 data"],"prefix":"10.1002","volume":"173","author":[{"given":"Lingfan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pediatrics The First People's Hospital of Xiaoshan  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The First People's Hospital of Xiaoshan  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01207-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-12765-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1282451"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31405-2"},{"key":"e_1_2_8_7_1","unstructured":"China's 90 million couples eligible for comprehensive two\u2010child policy 60% are over 35\u2009years old 2016.https:\/\/www.gov.cn\/xinwen\/2016\u201001\/11\/content_5032116.htm"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175696"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-023-15050-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.2022648"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"46","article-title":"Epidemiological trends of subarachnoid hemorrhage at global, regional, and national level: a trend analysis study from 1990 to 2021","volume":"11","author":"Lv B","year":"2024","journal-title":"Mil Med Res"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000705"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.10.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000000927"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85944"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2011.05.087"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.112274"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40806-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-016-0181-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2022.02.015"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.13.04161"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003047"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17249517"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-024-06931-z"},{"key":"e_1_2_8_25_1","unstructured":"Maternal and child health care law of the People's Republic of China.https:\/\/www.gov.cn\/guoqing\/2021\u201010\/29\/content_5647619.htm"},{"key":"e_1_2_8_26_1","unstructured":"Notice of the Ministry of Health on Issuing the \u201cTechnical Standards for Newborn Disease Screening\u201d 2004.http:\/\/www.nhc.gov.cn\/zwgk\/wtwj\/201304\/3314d7c0cb74432eaffc71ca9560e681.shtml"},{"key":"e_1_2_8_27_1","unstructured":"Notice of the Ministry of Health on Issuing the \u201cTechnical Standards for Newborn Disease Screening (2010 Edition)\u201d.2010http:\/\/www.nhc.gov.cn\/fys\/s3585\/201012\/170f29f0c5c54d298155631b4a510df0.shtml"},{"key":"e_1_2_8_28_1","unstructured":"The Central Committee of the Communist Party of China and the State Council Issue \u201cHealthy China 2030\u201d Planning Outline 2016.https:\/\/www.gov.cn\/zhengce\/2016\u201010\/25\/content_5124174.htm"},{"key":"e_1_2_8_29_1","unstructured":"Notice of the State Council on Issuing the Program for the Development of Chinese Women and the Program for the Development of Chinese Children 2001.https:\/\/www.gov.cn\/gongbao\/content\/2001\/content_60887.htm"},{"key":"e_1_2_8_30_1","unstructured":"Statistical Monitoring Report on the Implementation of the Program for the Development of Chinese Women (2011\u20102020) in 2019 2020.https:\/\/www.gov.cn\/xinwen\/2020\u201012\/19\/content_5571135.htm"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12862"},{"issue":"2","key":"e_1_2_8_32_1","first-page":"151","article-title":"Level of maternal education is a significant determinant of neonatal survival: a PEARL study analysis","volume":"25","author":"El Ansari W","year":"2015","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.18904"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3402\/gha.v6i0.19542"},{"issue":"2","key":"e_1_2_8_35_1","first-page":"91","article-title":"Assisted reproductive technology in China: compliance and non\u2010compliance","volume":"3","author":"Qiao J","year":"2014","journal-title":"Transl Pediatr"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14647273.2021.1969043"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7124362"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2021.100522"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(21)00298-9"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.31162"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-022-00670-x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904308"},{"issue":"1","key":"e_1_2_8_43_1","article-title":"Prevalence of fetal inflammatory response syndrome and villitis of unknown etiology in the placenta of Saudi women and their association with baby sex","volume":"14","author":"Aldahmash W","year":"2024","journal-title":"Life (Basel)"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00022.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2021.02.113"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1243364"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934356"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-018-0185-z"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2024.2334850"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181c09aec"},{"issue":"4","key":"e_1_2_8_51_1","first-page":"1330","article-title":"Investigation and analysis of non\u2010ABO hemolytic disease of the newborn","volume":"29","author":"Zheng YL","year":"2021","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403095"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2019"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3698"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02850-x"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.867715"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogn.2020.02.003"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2022.101345"},{"key":"e_1_2_8_59_1","unstructured":"Organization WH.Joint low birthweight estimates.https:\/\/www.who.int\/teams\/nutrition\u2010and\u2010food\u2010safety\/monitoring\u2010nutritional\u2010status\u2010and\u2010food\u2010safety\u2010and\u2010events\/joint\u2010low\u2010birthweight\u2010estimates"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(20)30161-3"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:12:21Z","timestamp":1777561941000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,4]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ijgo.70709"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70709","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,4]]},"assertion":[{"value":"2025-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}