{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:00:31Z","timestamp":1785463231796,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J011225"],"award-info":[{"award-number":["2023J011225"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024ZD01005"],"award-info":[{"award-number":["2024ZD01005"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between maternal hypertensive disorders of pregnancy (HDP) and childhood neurodevelopmental disorders (NDD) by Mendelian randomization (MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A two\u2010sample MR analysis was conducted to evaluate the causal effects of HDP, including gestational hypertension (GH), pre\u2010eclampsia superimposed on chronic hypertension, and pre\u2010eclampsia or eclampsia on childhood NDD, such as cerebral palsy (CP), autism spectrum disorder (ASD), and hyperkinetic disorders (HD). The exposure and outcome data were extracted from the FinnGen database. As the genetic and phenotypic data used were from previously collected resources, the analysis of FinnGen data in this study was a retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two\u2010sample MR analysis did not identify a significant causal relationship between maternal HDP and childhood NDD: GH with CP (odds ratio [OR] 1.05, 95% confidence interval [CI] 0.81\u20131.35), ASD (OR 1.04, 95% CI 0.83\u20131.29), and HD (OR 1.02, 95% CI 0.91\u20131.15); pre\u2010eclampsia superimposed on chronic hypertension with CP (OR 1.03, 95% CI 0.88\u20131.21), ASD (OR 1.02, 95% CI 0.85\u20131.23), and HD (OR 1, 95% CI 0.94\u20131.05); pre\u2010eclampsia or eclampsia with CP (OR 1.07, 95% CI 0.82\u20131.40), ASD (OR 0.90, 95% CI 0.69\u20131.18), and HD (OR 0.90, 95% CI 0.80\u20131.01). The MR\u2010Egger intercept did not detect potential pleiotropy (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05), thereby the results were considered unbiased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Maternal HDP did not increase the risk of childhood NDD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70724","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T14:42:56Z","timestamp":1767624176000},"page":"1372-1382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal hypertensive disorders of pregnancy and childhood neurodevelopmental disorders: A two\u2010sample Mendelian randomization"],"prefix":"10.1002","volume":"173","author":[{"given":"Baoquan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Health Management Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044160"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10803"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.133"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4347-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.12.027"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-021-01141-w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2583"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050963"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-009-0903-4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2171753"},{"key":"e_1_2_11_15_1","unstructured":"R Core Team.R: R: A language and environment for statistical computing.2013."},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0854"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0794-9"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.14140"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13430"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9030385"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.6.618"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.2.F88"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152637"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.11.024"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009400"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6752.587"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.20.2669"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.95.2.263"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7325"}],"container-title":["International Journal of Gynecology &amp; 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