{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:00:36Z","timestamp":1785463236997,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113\u20102314\u2010B\u2010016\u2010001\u2010MY2"],"award-info":[{"award-number":["NSTC 113\u20102314\u2010B\u2010016\u2010001\u2010MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 110\u20102314\u2010B\u2010038\u2010058"],"award-info":[{"award-number":["MOST 110\u20102314\u2010B\u2010038\u2010058"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111\u20102314\u2010B\u2010038\u2010110\u2010MY2"],"award-info":[{"award-number":["MOST 111\u20102314\u2010B\u2010038\u2010110\u2010MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022871","name":"National Defense Medical Center","doi-asserted-by":"publisher","award":["MND\u2010MAB\u2010D\u2010113071"],"award-info":[{"award-number":["MND\u2010MAB\u2010D\u2010113071"]}],"id":[{"id":"10.13039\/100022871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010E\u2010113267"],"award-info":[{"award-number":["TSGH\u2010E\u2010113267"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH\u2010D\u2010114119"],"award-info":[{"award-number":["TSGH\u2010D\u2010114119"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018493","name":"Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["113TWS\u2010W13"],"award-info":[{"award-number":["113TWS\u2010W13"]}],"id":[{"id":"10.13039\/100018493","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the practicability of self\u2010collected tampons with the MPap assay for endometrial cancer (EC) detection, by comparing with the results of cervical swabs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 85 women at Tri\u2010Service General Hospital (TSGH) were included to directly compare the performance of physician\u2010collected swabs and self\u2010collected tampons. An additional cohort of 39 self\u2010collected tampons from patients at Shuang Ho Hospital (SHH) was included for further validation. The effects of age, body mass index (BMI), and\n                      <jats:italic>BHLHE22<\/jats:italic>\n                      and\n                      <jats:italic>CDO1<\/jats:italic>\n                      methylation levels on MPap test performance were analyzed across samples from patients with and without EC. The performance of the MPap test is presented as percentage of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy (ACC). The Pearson's correlation test was used to examine the association between swab and tampon in the MPap test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The area under the curve (AUC) of MPap to detect EC in 85 swabs and tampons both were 0.94 (0.88\u20131.00). The sensitivity, specificity, PPV, NPV, and ACC of the two collection methods did not show significant differences. The testing results using a tampon were highly correlated with the results using a physician\u2010collected swab (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.6810,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Furthermore, the AUC of MPap to detect EC in 39 tampons was 0.97 (0.93\u20131.02). The sensitivity, specificity, PPV, NPV, and ACC were 90.48%, 94.44%, 95.00%, 89.47%, and 92.31%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data inferred the potential of the MPap test in early detection of EC using vaginal secretion collected by an intravaginal self\u2010collected tampon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70731","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:14:37Z","timestamp":1766139277000},"page":"1400-1407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <scp>DNA<\/scp>\n                    methylation assay (\n                    <scp>MPap<\/scp>\n                    ) using self\u2010collected tampon versus cytology collection swab for endometrial cancer detection"],"prefix":"10.1002","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-3671","authenticated-orcid":false,"given":"Kuo\u2010Min","family":"Su","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, College of Medicine National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Chang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Department of Obstetrics and Gynecology, Shuang Ho Hospital Taipei Medical University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9541-5403","authenticated-orcid":false,"given":"Yi\u2010Hsin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Tri\u2010Service General Hospital National Defense Medical University  Taipei Taiwan"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, College of Medicine National Defense Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-6382","authenticated-orcid":false,"given":"Po\u2010Hsuan","family":"Su","sequence":"additional","affiliation":[{"name":"College of Health Technology National Taipei University of Nursing and Health Sciences  Taipei 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