{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:00:39Z","timestamp":1785463239646,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The main objective was to describe women with fibroids who were treated with ultrasound\u2010guided high intensity focused ultrasound (USgHIFU) at the Chris Hani Baragwanath Academic Hospital (CHBAH) and to evaluate the outcomes at least 6\u2009months after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross\u2010sectional study using retrospectively collected data of women treated between November 2015 and December 2018 with USgHIFU at CHBAH. A clinical database that was used at the USgHIFU clinic and medical files were reviewed. The following data were retrieved; demographic information, characteristics of the fibroid (size, number, position, magnetic resonance imaging [MRI] intensity), symptoms before and after the procedure. Variables are described using descriptive statistics and were compared using a McNemar's chi2,\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test or Wilcoxon sign rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age, median body mass index (BMI) and median parity was 35\u2009years (standard deviation [SD] \u00b15.43), BMI of 25.3 (interquartile range [IQR]: 22.31\u201329.05), parity 0 (IQR: 0\u20131; range: 0\u20136), respectively. The presenting symptoms were dysmenorrhea (85.41%), infertility (50.92%) and menorrhagia (67.69%). The proportion of dysmenorrhea decreased from 84.10% before treatment to 54.06% after treatment. Menorrhagia was reduced from 66.08% to 41.34%. The median size of fibroids changed from 38.00 to 26.88\u2009cm\n                      <jats:sup>3<\/jats:sup>\n                      . These changes were statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first USgHIFU study that reports outcomes in a South African population. The treatment has resulted in a noticeable alleviation of symptoms and a measurable reduction in fibroid size and this was statistically significant and clinically relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70742","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T09:45:33Z","timestamp":1765791933000},"page":"1408-1412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in symptoms and fibroid characteristics in women treated with ultrasound\u2010guided high intensity focused ultrasound (\n                    <scp>USgHIFU<\/scp>\n                    ) at Chris Hani Baragwanath Academic Hospital"],"prefix":"10.1002","volume":"173","author":[{"given":"Raphaela","family":"Setzen","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Setzen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"},{"name":"Department of Obstetrics &amp; Gynecology Chris Hani Baragwanath Academic Hospital  Johannesburg Gauteng South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Van Dyk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayanda","family":"Sengane","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomvuyo","family":"Manyatsi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalya","family":"Sarubdeo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3185-8264","authenticated-orcid":false,"given":"Yasmin","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology University of the Witwatersrand  Johannesburg South Africa"},{"name":"Department of Obstetrics &amp; Gynecology Chris Hani Baragwanath Academic Hospital  Johannesburg Gauteng South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.grf.0000159538.27221.8c"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000136079.62513.39"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.01.052"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199807000-00006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08156-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014566"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000223"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000547.pub2"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v2.i1.8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.2.2105017"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1411029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.15086"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14745"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2016.22.2.59"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8362"},{"key":"e_1_2_10_17_1","volume-title":"StatPearls","author":"Rezk A","year":"2023"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2020.09.013"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1807617"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109801"}],"container-title":["International Journal of Gynecology &amp; 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