{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:28:25Z","timestamp":1792481305133,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser (MRKH) syndrome is a rare congenital anomaly of the M\u00fcllerian ducts and represents the second most common cause of primary amenorrhea, accounting for 10%\u201315% of cases. Despite its significance, limited data exist regarding its clinical profile and associated anomalies in the Indian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine the prevalence of MRKH syndrome among women presenting with primary amenorrhea at a tertiary care center in South India and to describe their clinical profiles and associated anomalies using the Vagina Cervix Uterus Adnexa\u2010associated Malformation (VCUAM) classification system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted over 15\u2009years (January 2008 to December 2022) including women diagnosed with MRKH syndrome based on inclusion criteria: primary amenorrhea, normal secondary sexual characteristics, 46\u2010XX karyotype, and normal serum follicle\u2010stimulating hormone levels. Data were extracted from medical records and analyzed using SPSS v25.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 340 women with primary amenorrhea, 181 (60%) were diagnosed with MRKH syndrome. The mean age at presentation was 21\u2009years. The predominant complaint was non\u2010attainment of menarche (66.8%), with 16.5% reporting cyclical abdominal pain. Type 1 MRKH was most common (78.9%), followed by M\u00fcllerian duct aplasia\u2013renal agenesis\u2013cervicothoracic somite dysplasia (MURCS) association (16.5%). Renal anomalies (15.5%) were the most frequent extragenital malformations. All women had vaginal and cervical agenesis (V5bC2b). Uterine anomalies included bilateral aplasia (89.1%), unilateral aplasia (0.6%), and hypoplasia (10.5%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MRKH syndrome is a significant cause of primary amenorrhea, with notable extragenital anomalies, especially renal. Systematic evaluation using the VCUAM classification enables comprehensive assessment, aiding in individualized and multidisciplinary care strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70825","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:31:02Z","timestamp":1770208262000},"page":"375-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, clinical profile, and associated anomalies with women with Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser syndrome in a tertiary care center: A cross\u2010sectional study"],"prefix":"10.1002","volume":"174","author":[{"given":"Benedict","family":"Vency","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-5113","authenticated-orcid":false,"given":"Minakshi","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily Divya","family":"Ebenezer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3915-5590","authenticated-orcid":false,"given":"Lilly","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-3987","authenticated-orcid":false,"given":"Pushplata","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Berek & Novak's gynecology","author":"Berek JS","year":"2012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-4667.2012.00097.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0000000000000087"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2018.07.007"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-13"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01491-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/GMIT.GMIT_13_19"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew220"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2021.02.033"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.23211"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4372-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1368990"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/29016.10317"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2014.07.019"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-018-1575-3"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.06.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12883"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-10-57"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.05.036"}],"container-title":["International Journal of Gynecology &amp; 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