{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:08:19Z","timestamp":1784300899093,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study examines the associations between the loop electrosurgical excision procedure (LEEP) and the risk of adverse perinatal outcomes among women who have undergone primary human papillomavirus (HPV) screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this longitudinal cohort study, women who received HPV screening and were followed up in a randomized trial in British Columbia (BC), Canada, were linked to a province\u2010wide perinatal registry; those with a singleton live birth after screening (index birth) were included (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20091765). Adjusted odds ratios (aORs) were calculated to compare the risk of preterm birth (PTB, gestational week &lt;37) and low birthweight (LBW, birthweight &lt;2500\u2009g) by LEEP status prior to index birth. Crude rates of LEEP, PTB, and LBW in the HPV\u2010screened cohort (HPV group) and the provincial cytology\u2010screened population (cytology group) were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Risks of PTB and LBW were not significantly higher in LEEP\u2010treated women (PTB: aOR 1.32, 95% confidence interval [CI], 0.63\u20132.80); LBW: (aOR 1.33, 95% CI, 0.50\u20133.55). In the HPV and cytology groups, 1.5% and 0.6% were referred for LEEP, respectively. Rates of PTB were 9.1% and 10.5% and LBW were 4.8% and 6.1% in the HPV and cytology groups, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among HPV\u2010screened women, the risks of PTB and LBW were not statistically significantly associated with LEEP. HPV\u2010based screening might lead to more treatments than cytology\u2010based screening, yet the overall risks of PTB and LBW remained similar across groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70872","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:24:27Z","timestamp":1771475067000},"page":"793-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loop electrosurgical excision procedure and perinatal outcomes post\u2010human papillomavirus cervical screening: A longitudinal cohort study"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-3897","authenticated-orcid":false,"given":"Quan","family":"Hong","sequence":"first","affiliation":[{"name":"Women's Health Research Institute BC Women's Hospital and Health Services  Vancouver British Columbia Canada"},{"name":"Faculty of Medicine University of British 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