{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:23:12Z","timestamp":1790770992327,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Melatonin, a hormone produced by the pineal gland and reproductive tissues, regulates circadian rhythms, antioxidant activity, and fertility. Artificial light at night suppresses melatonin, leading to increased oxidative stress and compromised sperm and egg quality. During assisted reproductive technologies (ART), light exposure generates harmful reactive oxygen species (ROS), impairing gametes and embryos. Melatonin counteracts ROS, enhances antioxidant defenses, and improves embryo development, blastocyst formation, and implantation. This review examines melatonin's protective role in reproduction and how light exposure affects fertility. Understanding these mechanisms could enhance the success of ART and fertility treatments.<\/jats:p>","DOI":"10.1002\/ijgo.70882","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:37:26Z","timestamp":1771475846000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Visible light, oxidative stress, and reproduction: The protective role of melatonin"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-1224","authenticated-orcid":false,"given":"Parvaneh","family":"Behi Shahreza","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayyebeh","family":"Zamani\u2010Badi","sequence":"additional","affiliation":[{"name":"Anatomical Sciences Research Center, Institute for Basic Sciences Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golnaz","family":"Shafiei","sequence":"additional","affiliation":[{"name":"Anatomical Sciences Research Center, Institute for Basic Sciences Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atefeh","family":"Jamal","sequence":"additional","affiliation":[{"name":"Anatomical Sciences Research Center, Institute for Basic Sciences Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-8072","authenticated-orcid":false,"given":"Ghazaleh","family":"Moshkdanian","sequence":"additional","affiliation":[{"name":"Anatomical Sciences Research Center, Institute for Basic Sciences Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000183593.24583.7c"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010092"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0121"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8209"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-021-03139-4"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030477"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2022.12.003"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2023.108490"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v22i8.17262"},{"issue":"4","key":"e_1_2_16_11_1","first-page":"599","article-title":"Melatonin pretreated blastocysts along with calcitonin administration improved implantation by upregulation of heparin binding\u2010epidermal growth factor expression in murine endometrium","volume":"19","author":"Moghani\u2010Ghoroghi F","year":"2017","journal-title":"Cell J"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-021-04151-z"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14040644"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413240"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.32718\/ujvas8-1.08"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12010086"},{"issue":"12","key":"e_1_2_16_17_1","first-page":"3252","article-title":"The role of melatonin in pregnancy and the health benefits for the newborn","volume":"10","author":"Verteramo R","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666230417103201"},{"issue":"5","key":"e_1_2_16_19_1","first-page":"470","article-title":"Mitochondria\u2010derived reactive oxygen species mediate blue light\u2010induced death of retinal pigment epithelial cells\u00b6","volume":"79","author":"King A","year":"2004","journal-title":"Photochem Photobiol"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2004.07.022"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.121195"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400453R"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.4.764"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9061-2018-0931"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.08.020"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab117"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4015874"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.589925"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810043"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1545593"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242015056"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci9070309"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12615"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.155148"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2018.02.004"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0172-9"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0256-1"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706687104"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.01.036"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202484"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118445"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12216"},{"issue":"4","key":"e_1_2_16_44_1","first-page":"599","article-title":"Melatonin pretreated blastocysts along with calcitonin administration improved implantation by upregulation of heparin binding\u2010epidermal growth factor expression in murine endometrium","volume":"19","author":"Moghani\u2010Ghoroghi F","year":"2017","journal-title":"Cell J (Yakhteh)"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115467"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.106450"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2024.863-870"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20849"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology14050491"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312403"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/1984-3143-ar2022-0038"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2002.tb02281.x"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122927"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.187"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14243592"},{"issue":"9","key":"e_1_2_16_56_1","article-title":"Methods for assessing oocyte quality: a review of literature","volume":"10","author":"Lemseffer Y","year":"2022","journal-title":"Biomedicine"},{"issue":"6","key":"e_1_2_16_57_1","article-title":"Melatonin upregulates ErbB1 and ErbB4, two primary implantation receptors, in pre\u2010implantation mouse embryos","volume":"20","author":"Moshkdanian G","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-64-4-865"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-015-0368-5"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2008.01230.x"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.09.009"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9385-8"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/205891581200300203"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.02.003"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509016"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402060308"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv034"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0840197"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11050797"},{"issue":"2","key":"e_1_2_16_70_1","first-page":"139","article-title":"Embryo and its mitochondria","volume":"10","author":"May\u2010Panloup P","year":"2021","journal-title":"Embryo Mitochondria Antioxid"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115885"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.853999"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139814"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa054"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1429252"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1366992"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-022-03123-4"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010300"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-016-9968-4"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118068"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70882","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:52:52Z","timestamp":1784299972000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,18]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ijgo.70882"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70882","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,18]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}