{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:57:13Z","timestamp":1791817033125,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intrauterine balloon tamponade (IUBT) and uterine gauze packing (UGP) are commonly used to manage postpartum hemorrhage (PPH) that is unresponsive to first\u2010line therapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study compares the efficacy and safety of the IUBT and UGP in the management of PPH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We searched the Cochrane Central Register of Controlled Trials in the Cochrane Library. MEDLINE and Embase databases from their inception to June 2024. We included randomized controlled trials (RCTs) that compared the IUBT to the UGP for the management of PPH. The primary outcomes were maternal mortality and blood loss. The secondary outcomes included blood transfusion, additional interventions, organ injury, and infection. We assessed the risk of bias for each outcome reported by the included studies. Meta\u2010analysis was performed using random\u2010effects models. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four trials involving 577 patients were included. Moderate\u2010certainty evidence revealed no difference in mortality rates. IUBT might reduce blood loss volume (mean difference \u2212276.2\u2009mL, 95% confidence interval [CI] \u2212563.0 to 10.6; low certainty) and transfusion (very low certainty) compared to UGP. IUBT might increase the need for additional interventions, but the evidence for this is very uncertain (risk ratio [RR] 2.57, 95% CI 0.89\u20137.40; very low certainty). IUBT likely reduces organ injury (RR 0.65, 95% CI 0.45\u20130.95) and infection (RR 0.47, 95% CI 0.38\u20130.59) compared to UGP (moderate certainty).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The IUBT might reduce blood loss, transfusion, and complications in PPH compared to UGP, although the certainty of evidence is low. Larger, high\u2010quality RCTs are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70888","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:57:21Z","timestamp":1773010641000},"page":"599-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intrauterine balloon tamponade versus uterine gauze packing for postpartum hemorrhage: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-0613","authenticated-orcid":false,"given":"Yuto","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hosokawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Showa Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Showa Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Showa Medical University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Human Health Sciences Graduate School of Medicine, Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Kumamoto General Hospital  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Center for Maternal, Fetal, and Neonatal Medicine, Saitama Medical Center Saitama Medical University  Kawagoe Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine Nihon University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(14)70227-x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181d74898"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.WHO recommendation on uterine balloon tamponade for the treatment of postpartum haemorrhage. Geneva: World Health Organization; 2021. Accessed April 28 2025.https:\/\/www.who.int\/publications\/i\/item\/9789240013841."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14178"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.11.1287"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.06.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000019221"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2021-0533"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xagr.2022.100135"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_12_1","unstructured":"MakinoY HosokawaY ArakakiT MatsunagaS KatoR FurutaM.Intrauterine balloon tamponade versus uterine gauze packing for postpartum hemorrhage: A systematic review and meta\u2010analysis. PROSPERO 2024 CRD42024563118.https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD42024563118."},{"key":"e_1_2_10_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins JP","year":"2024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21649\/akemu.v24iS.2581"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1566309"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.53350\/pjmhs22166242"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.15960"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201900376"},{"key":"e_1_2_10_21_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"McKenzie JE","year":"2024"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14156"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13550"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1962288"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2024.2349957"},{"key":"e_1_2_10_26_1","volume-title":"Introduction to Meta\u2010Analysis","author":"Borenstein M","year":"2019"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.70888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.70888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:52:43Z","timestamp":1784299963000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.70888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ijgo.70888"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.70888","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"2025-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}