{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:20:53Z","timestamp":1789802453148,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intrauterine adhesions (IUAs), or Asherman's syndrome, are common complications of intrauterine surgery, such as hysteroscopic myomectomy, leading to menstrual disturbances and infertility. Postoperative inflammation is thought to drive adhesion formation, but the predictive value of specific inflammatory biomarkers remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a prospective observational study of 150 women aged 19\u201345\u2009years undergoing hysteroscopic resection of submucosal fibroids. Serum C\u2010reactive protein (CRP), interleukin\u20106 (IL\u20106), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) levels were measured preoperatively, 48\u2009h postoperatively, and at 3\u2009months. IUAs were evaluated at 12\u2009weeks by second\u2010look hysteroscopy and graded by the American Fertility Society criteria. Logistic regression and receiver operating characteristic analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 135 patients who completed follow\u2010up, 40 (30.8%) developed IUAs (20 mild, 12 moderate, and eight severe). Postoperative (48\u2010h) serum IL\u20106 and CRP levels increased significantly in patients who developed adhesions compared with those who did not (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), while postoperative TNF\u2010\u03b1 differences were less pronounced. IL\u20106 showed the strongest correlation with adhesion severity (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u2009=\u20090.53) and was an independent predictor of moderate\u2010to\u2010severe IUA risk (adjusted odds ratio [OR]\u2009=\u20091.25 per pg\/mL, 95% confidence interval [CI] 1.10\u20131.42). CRP was also predictive (OR\u2009=\u20091.30 per mg\/L, 95% CI 1.05\u20131.60). IL\u20106 had the best discriminative ability (area under the curve [AUC]\u2009=\u20090.80), outperforming CRP (AUC\u2009=\u20090.72) and TNF\u2010\u03b1 (AUC\u2009=\u20090.65).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Perioperative elevations in IL\u20106 and CRP are strongly associated with adhesion formation after hysteroscopic myomectomy. These markers might support risk\u2010stratified postoperative surveillance in future multicenter studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70940","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T06:07:03Z","timestamp":1774678023000},"page":"1580-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inflammatory cytokine signatures predict postoperative intrauterine adhesions after hysteroscopic fibroid resection: Evidence from a prospective cohort"],"prefix":"10.1002","volume":"174","author":[{"given":"Yan","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0330-5256","authenticated-orcid":false,"given":"Yuqin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2024.02.004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/450658"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105175"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-05164-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07498-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15080955"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107201"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.10.007"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-118"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2025.2537227"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab039"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.09.015"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13010073"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13808"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S527637"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.20035"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1638604"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04298-2"},{"issue":"2","key":"e_1_2_12_20_1","first-page":"137","article-title":"Adhesions and anti\u2010adhesion systems highlights","volume":"11","author":"Torres\u2010De La Roche LA","year":"2019","journal-title":"Facts Views Vis Obgyn"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2413-5449"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340802322265"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.7941"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.86968"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.ceog5104102"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239709"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dead194"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42155-025-00589-1"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.31083\/ceog26348"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30338-8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.09.028"}],"container-title":["International Journal of Gynecology &amp; 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