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<jats:title>Methods<\/jats:title>\n                    <jats:p>The study was designed as a prospective cohort study of unvaccinated pregnant and postpartum women with SARS\u2010CoV\u20102 infection diagnosed by quantitative reverse transcription polymerase chain reaction between May 2020 and April 2021 at a maternal referral center. Initially, 111 participants were identified, and 50 presented with conditions for genome sequencing and further analysis. The SARS\u2010CoV\u20102 genome was subjected to next\u2010generation sequencing in eligible cases. Sociodemographic characteristics, background, and clinical and obstetric outcomes were compared according to the SARS\u2010CoV\u20102 genomic data (VOC vs. non\u2010VOC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the sequenced cases, 18 were classified as VOC, among which 14 were Gamma cases and four Alpha. Oxygen desaturation, hospitalization, intensive care unit admission, invasive ventilation, and maternal death were significantly higher in SARS\u2010CoV\u20102 VOC\u2010infected than in non\u2010VOC\u2010infected cases. All three cases of maternal death were classified as VOC, including two Gamma and one Alpha.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pregnant and postpartum people presented with an increased morbidity and mortality due to COVID\u201019 caused by SARS\u2010CoV\u20102 VOC, especially Gamma. The increased risk of clinical severity in the unvaccinated obstetric population underscores the importance of addressing the repercussions of the SARS\u2010CoV\u20102 genomic evolution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70985","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:05:04Z","timestamp":1774947904000},"page":"1655-1664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gamma\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 variant of concern infection repercussions on pregnancy outcomes: A translational cohort study"],"prefix":"10.1002","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9406-4256","authenticated-orcid":false,"given":"Guilherme M.","family":"Nobrega","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Granja","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"},{"name":"Biodiversity Research Centre Federal University of Roraima  Boa Vista Roraima Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariene R.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana S.","family":"Mofatto","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Toledo\u2010Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Forato","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla P.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Viruses, Department of Genetics, Evolution, Microbiology and Immunology Institute of Biology, University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Paulo S.","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana G.","family":"Luz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliane J.","family":"Lajos","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina C.","family":"Ribeiro\u2010do\u2010Valle","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele A.","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, School of Medical Sciences University of Campinas  Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila C. 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