{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:39Z","timestamp":1790866659047,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine if those screened as high\u2010risk for preterm pre\u2010eclampsia at first\u2010trimester Fetal Medicine Foundation (FMF)\u2010based screening and given aspirin are at higher risk of adverse pregnancy outcomes, even after adjusting for pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 1623 ethnically Chinese women who received FMF\u2010based pre\u2010eclampsia screening, and subsequently delivered within our hospital system. Pregnancy outcomes were compared between screen\u2010positives (high risk, given aspirin) and screen\u2010negatives, and adjusted by pre\u2010eclampsia status and any hypertension in pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for pre\u2010eclampsia, screen\u2010positives still delivered earlier (\u22120.7\u2009weeks,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), with a higher rate of preterm birth (PTB) before 37\u2009weeks (odds ratio [OR] 2.413,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002). Birth weight centiles in the screen\u2010positive group were lower (\u22128.3,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001), with small\u2010for\u2010gestational\u2010age (SGA) being more common in the screen\u2010positive group (OR 2.697,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Emergency cesarean was more common (OR 2.943,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), rate of admission to neonatal intensive care unit was higher (OR 2.044,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014), and stillbirths were more common (OR 5.131,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The risks for SGA\/fetal growth restriction and PTB were significantly higher in those who screened positive at FMF first\u2010trimester pre\u2010eclampsia screening, even after adjusting for pre\u2010eclampsia, and they may benefit from increased surveillance. Components of FMF\u2010based first\u2010trimester pre\u2010eclampsia screening overlap substantially with uteroplacental great obstetrical syndromes, and help to identify a broader placental\u2010risk phenotype. Future research may explore how this information could be further operationalized\u2014through refinement of risk thresholds and incorporation of adjunctive strategies. Nevertheless, the lack of highly effective strategies to further stratify and prevent SGA\/fetal growth restriction and spontaneous PTB remains a challenge.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.70995","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:40:54Z","timestamp":1775025654000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010trimester pre\u2010eclampsia screening and adverse pregnancy outcomes beyond pre\u2010eclampsia"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-0831","authenticated-orcid":false,"given":"Linus L. T.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern Hospital  Chai Wan Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suet Yin","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern Hospital  Chai Wan Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1486-761X","authenticated-orcid":false,"given":"Lin Wai","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Pamela Youde Nethersole Eastern Hospital  Chai Wan Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12741"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S283239"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18816"},{"issue":"650","key":"e_1_2_9_5_1","first-page":"e1","article-title":"Prospective evaluation of screening performance of first\u2010trimester prediction models for preterm preeclampsia in an Asian population","volume":"221","author":"Chaemsaithong P","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17613"},{"issue":"204","key":"e_1_2_9_8_1","first-page":"e1","article-title":"Pregnancy outcomes in nulliparous women with positive first\u2010trimester preterm preeclampsia screening test: the great obstetrical syndromes cohort study","volume":"224","author":"Boutin A","year":"2021","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17560"},{"issue":"452","key":"e_1_2_9_10_1","first-page":"e1","article-title":"First trimester risk of preeclampsia and rate of spontaneous birth in patients without preeclampsia","volume":"231","author":"Cavoretto PI","year":"2024","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24915"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19077"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2025.10.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.3.F229"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19112"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32973-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17673"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29255"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00393-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.11.1356"},{"issue":"615","key":"e_1_2_9_22_1","first-page":"e1","article-title":"Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology","volume":"227","author":"Romero R","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4672"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12802"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2024.102732"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/1354750X.2025.2475474"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1806"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17814"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321694"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2020.06.011"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14605"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27447"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.13837"}],"container-title":["International Journal of Gynecology &amp; 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