{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:41Z","timestamp":1790866661936,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates the associations of preconception polycystic ovarian syndrome (PCOS) and pregnancy conditions (gestational diabetes mellitus (GDM) and gestational hypertension) overall and by maternal obesity and plurality, and the associations of PCOS and birth outcomes overall and by GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a pooled cross\u2010sectional study using the Pregnancy Risk Assessment Monitoring System (PRAMS) data from 2016 to 2021 for population\u2010based jurisdictions that included PCOS questions (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009111\u2009417). The PRAMS population\u2010based random sample is weighted to give a representative sample of US women who gave birth in participating jurisdictions. The study exposure, outcomes, and covariates were measured using study questionnaires and birth certificate data. We used logistic regression to estimate confounder\u2010adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Models accounted for sampling weights and were adjusted for maternal demographics and pregnancy characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Approximately 6.5% (95% CI: 6.38\u20136.83) of women reported having preconception PCOS. Women with PCOS were more likely to develop GDM (aOR\u2009=\u20091.42; 95% CI\u2009=\u20091.27\u20131.58), to have gestational hypertension (aOR\u2009=\u20091.38; 95% CI\u2009=\u20091.25\u20131.52), to undergo cesarean delivery (aOR\u2009=\u20091.14; 95% CI\u2009=\u20091.05\u20131.24), to deliver a low birthweight infant (aOR\u2009=\u20091.32; 95%, CI\u2009=\u20091.20\u20131.45), and to have a preterm birth (aOR\u2009=\u20091.25; 95% CI\u2009=\u20091.12\u20131.39), compared to those without PCOS. Results were consistent across subgroups defined by maternal obesity, plurality, and GDM (as applicable).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Findings fill a gap in research using recent population\u2010based US representative data to emphasize the importance of early detection and tailored management strategies for women with PCOS to mitigate the risks of pregnancy complications and support the need for targeted interventions to improve maternal and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71006","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:35:12Z","timestamp":1775820912000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polycystic ovarian syndrome and perinatal outcomes: A\u00a0population\u2010based pooled cross\u2010sectional study"],"prefix":"10.1002","volume":"175","author":[{"given":"Raegan A.","family":"Holek","sequence":"first","affiliation":[{"name":"College of Health Professions, School of Interdisciplinary Health Grand Valley State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Rossow","sequence":"additional","affiliation":[{"name":"District Health Department  Ludington Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-6678","authenticated-orcid":false,"given":"Sarah","family":"Nechuta","sequence":"additional","affiliation":[{"name":"College of Health Professions, School of Interdisciplinary Health Grand Valley State University  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.04.010"},{"key":"e_1_2_10_3_1","unstructured":"ShuklaS RasquinLI AnastasopoulouC et\u00a0al.Polycystic Ovarian Syndrome. [Updated 2025 Jul 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan. Available from:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459251\/."},{"key":"e_1_2_10_4_1","unstructured":"Centers for Disease Control and Prevention.Diabetes and PCOS (Polycystic Ovary Syndrome).2024Available from:https:\/\/www.cdc.gov\/diabetes\/risk\u2010factors\/pcos\u2010polycystic\u2010ovary\u2010syndrome.html. Last accessed 03\u201016\u201026."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18544\/PEDM-23.04.0094"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2023.2177536"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml036"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.045"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004863"},{"issue":"12","key":"e_1_2_10_10_1","article-title":"Gestational diabetes mellitus in the setting of polycystic ovarian syndrome: A systematic review","volume":"15","author":"Slouha E","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6309"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2021.1931066"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa099"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-067946"},{"key":"e_1_2_10_15_1","unstructured":"Centers for Disease Control and Prevention.2024. Available from:https:\/\/www.cdc.gov\/prams\/about\/index.html. Last accessed 03\u201016\u201026."},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304563"},{"key":"e_1_2_10_17_1","unstructured":"Centers for Disease Control and Prevention.2016 PRAMS Response Rate Table.2024Available from:https:\/\/www.cdc.gov\/prams\/php\/data\u2010research\/2016\u2010response\u2010rate\u2010table.html. Last accessed 03\u201016\u201026"},{"key":"e_1_2_10_18_1","unstructured":"Centers for Disease Control and Prevention.2021 PRAMS Response Rate Table.2024Available from:https:\/\/www.cdc.gov\/prams\/php\/data\u2010research\/2021\u2010response\u2010rate\u2010table.html. Last accessed 03\u201016\u201026"},{"key":"e_1_2_10_19_1","unstructured":"Centers for Disease Control and Prevention.PRAMS Phase 8 Topic Reference Document.2024Available from:https:\/\/www.cdc.gov\/prams\/pdf\/questionnaire\/Phase\u20108\u2010Topics\u2010Reference_508tagged.pdf. Last accessed 03\u201016\u201026"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"566","article-title":"Self\u2010administered questionnaire to screen for polycystic ovarian syndrome","volume":"1","author":"Bedrick BS","year":"2020","journal-title":"Womens Health Rep (New Rochelle)"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac251"},{"issue":"6","key":"e_1_2_10_22_1","article-title":"Adverse pregnancy outcome in polycystic ovarian syndrome: A comparative study","volume":"14","author":"Pattnaik L","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa144"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000001185"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02394-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000695"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12514"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.07.025"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:23:00Z","timestamp":1790864580000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ijgo.71006"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71006","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,10]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}