{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:39Z","timestamp":1790866659000,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the prognostic value of neutrophil\u2010to\u2010lymphocyte ratio (NLR) in women with cervical cancer infected with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included women with cervical cancer with HIV infection who underwent primary treatment at a tertiary hospital in southern Thailand between 2005 and 2019. Overall survival (OS) and progression\u2010free survival (PFS) were analyzed using the Kaplan\u2013Meier method. Univariate and multivariate Cox regression analyses were used to determine the independent factors associated with OS and PFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 100 patients (median follow\u2010up time 37.63\u2009months), the 5\u2010year OS and PFS rates were 64.5% (95% confidence interval [CI]: 55.0\u201375.6) and 58.2% (95% CI: 48.6\u201369.6), respectively. In the multivariate analysis, high NLR (hazard ratio [HR]: 3.53, 95% CI: 1.58\u20137.91,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.002) and low equivalent total dose in 2\u2009Gy fractions at point A (HR 2.14, 95% CI: 1.02\u20134.49,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.045) were independent predictors of worse OS, while poor performance status (HR 6.73, 95% CI: 1.93\u201323.56,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), adenocarcinoma histology (HR 3.32, 95% CI: 1.43\u20137.72,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.005), and high NLR (HR 4.04, 95% CI: 1.87\u20138.73,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independent predictors of worse PFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High NLR independently predicts poor OS and PFS in women with cervical cancer with HIV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71016","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:35:30Z","timestamp":1776227730000},"page":"300-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil\u2010to\u2010lymphocyte ratio as a prognostic marker for survival outcomes in women with cervical cancer and HIV infection"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-2557","authenticated-orcid":false,"given":"Ingporn","family":"Jiamset","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-0378","authenticated-orcid":false,"given":"Kulisara","family":"Nanthamongkolkul","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-8962","authenticated-orcid":false,"given":"Walaiporn","family":"Kongkamsuan","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-8975","authenticated-orcid":false,"given":"Nungrutai","family":"Saeaib","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-8123","authenticated-orcid":false,"given":"Narumon","family":"Janmunee","sequence":"additional","affiliation":[{"name":"Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine Prince of Songkla University  Songkhla Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Cancer today [IARC website]. Accessed August 13 2025.http:\/\/gco.iarc.fr\/today\/home"},{"key":"e_1_2_11_3_1","unstructured":"UNAIDS.Global HIV & AIDS statistics fact sheet [UNAIDS website]. Accessed August 11 2025.https:\/\/www.unaids.org\/en\/resources\/fact\u2010sheet"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/oncm.25573"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.9613"},{"key":"e_1_2_11_6_1","article-title":"Prognostic role of baseline neutrophil\u2010to\u2010lymphocyte ratio in metastatic solid tumors","volume":"13","author":"Zucker A","year":"2020","journal-title":"Mol Clin Oncol"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10102199"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"S9","article-title":"Effects of radiation therapy on immunological and virological status in HIV\u2010infected cancer patients in Thailand: a multicenter prospective study","volume":"99","author":"Siraprapasiri P","year":"2016","journal-title":"J Med Assoc Thail"},{"key":"e_1_2_11_9_1","first-page":"137","article-title":"Treatment outcomes of cervical carcinoma in HIV\u2010infected patients","volume":"101","author":"Rongsriyam K","year":"2018","journal-title":"J Med Assoc Thail"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2020.100669"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12611"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2023.0062"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2020.04.002"},{"key":"e_1_2_11_14_1","volume-title":"Thailand National Guidelines on HIV\/AIDS Treatment and Prevention 2021\/2022","author":"Ruxrungtham K","year":"2022"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.08.038"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1461175"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-79071-x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000682"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7966625"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479521"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2939162"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4017"},{"key":"e_1_2_11_23_1","article-title":"High\u2010risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART\u2010suppressed HIV\u20101\u2010infected women","volume":"5","author":"Papasavvas E","year":"2016","journal-title":"Onco Targets Ther"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011592"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.040"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(88)90018-7"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:23:35Z","timestamp":1790864615000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ijgo.71016"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71016","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}