{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:57:27Z","timestamp":1790866647960,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To assess the role of fetal renal artery Doppler indices, specifically the pulsatility index (PI) and resistive index (RI), along with reduced fetal urine production rate (FUPR) in predicting fetal inflammatory response syndrome (FIRS) in women with preterm prelabor rupture of membranes (PPROM).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A prospective, observational study was conducted in a tertiary care center of 160 singleton pregnancies between 28 and 36\u2009weeks of gestation with PPROM. Fetal renal artery Doppler measurements (PI and RI) and FUPR estimation by measurement of bladder volume were performed weekly using ultrasound until delivery. At delivery, cord blood was collected for IL\u20106 quantification, and placental tissue was examined for histologic evidence of FIRS. FIRS was defined as IL\u20106 levels \u226511\u2009pg\/mL and\/or histopathologic findings of funisitis\/chorionic vasculitis. Statistical analyses including receiver operating characteristic (ROC) curves were performed, with\n P<\/jats:italic>\n \u2009<\u20090.05 considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 160 participants, 103 (64.4%) were diagnosed with FIRS. The mean IL\u20106 concentration was significantly higher in the FIRS group (210.40\u2009\u00b1\u2009133.70\u2009pg\/mL vs. 7.44\u2009\u00b1\u20092.01\u2009pg\/mL,\n P<\/jats:italic>\n \u2009<\u20090.001). Fetal renal Doppler indices were significantly elevated in the FIRS group (PI: 2.93\u2009\u00b1\u20090.08 vs. 2.41\u2009\u00b1\u20090.11,\n P<\/jats:italic>\n \u2009<\u20090.001; RI: 0.96\u2009\u00b1\u20090.04 vs. 0.88\u2009\u00b1\u20090.03,\n P<\/jats:italic>\n \u2009<\u20090.00). Reduced FUPR (<5th percentile for gestational age) was observed in 99% of FIRS cases. FUPR had significant inverse relationship with fetal renal Doppler indices. ROC analysis identified a PI \u22652.8 as the optimal cutoff for predicting FIRS, with 98.8% sensitivity and 100% specificity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Fetal renal artery Doppler indices offer a reliable, noninvasive method for early prediction of fetal inflammation, enabling timely interventions to improve maternal and neonatal outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.71040","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:19:27Z","timestamp":1777547967000},"page":"428-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal renal Doppler and urine production rate: Non\u2010invasive predictors of fetal inflammatory response syndrome in preterm prelabor rupture of membranes\u2014An observational study"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9196-0733","authenticated-orcid":false,"given":"Priya","family":"Samanta","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7672-0328","authenticated-orcid":false,"given":"Richa","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuchi","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Radiology University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Diwaker","sequence":"additional","affiliation":[{"name":"Department of Pathology University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Mehnridatta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Sachan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University College of Medical Sciences and GTB Hospital, University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200301000-00033"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"11","article-title":"Contemporary diagnosis and management of preterm premature rupture of membranes","volume":"1","author":"Caughey AB","year":"2008","journal-title":"Rev Obstet Gynecol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.958463"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101146"},{"issue":"3","key":"e_1_2_11_6_1","first-page":"303.e1","article-title":"Ultrasonographic approach to diagnosis of fetal inflammatory response syndrome: a tool for at\u2010risk fetuses?","volume":"215","author":"Mastrolia SA","year":"2016","journal-title":"Am J Obstet 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