{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:44:54Z","timestamp":1792176294488,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of low\u2010dose paroxetine (20\u2009mg\/day) compared with placebo for managing vasomotor symptoms (VMS) in women with surgical menopause.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a pilot randomized, double\u2010blind, placebo\u2010controlled trial conducted at the Instituto Hondure\u00f1o de Seguridad Social (IHSS), Tegucigalpa, Honduras, from January 30 to July 31, 2025. Women aged &lt;48\u2009years, within 6\u2009months of total hysterectomy with bilateral salpingo\u2010oophorectomy, and experiencing moderate\u2010to\u2010severe VMS (\u2265\u20097 episodes\/week) were eligible. Participants were randomized 1:1 to receive paroxetine 20\u2009mg\/day or matching placebo (folic acid 5\u2009mg) for 12\u2009weeks. The primary outcome was change in total Menopause Rating Scale (MRS) score. Secondary outcomes included quality of life (SF\u201036) and adverse events. Analysis followed the per\u2010protocol approach, with intention\u2010to\u2010treat sensitivity analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 150 women assessed, 90 were randomized. A total of 47 women in the paroxetine group and 43 in the placebo group completed follow\u2010up and were analyzed. At 12\u2009weeks, the paroxetine group showed greater reduction in total MRS score compared with placebo (mean 16.9\u2009\u00b1\u20097.7 vs. 22.6\u2009\u00b1\u20096.1; mean difference \u22125.7, 95% CI \u22128.6 to \u22122.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). SF\u201036 scores also improved more with paroxetine (91.0\u2009\u00b1\u20096.4 vs. 86.9\u2009\u00b1\u20094.8; mean difference 4.1, 95% CI 1.7 to 6.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001). Adverse events (headache, fatigue, drowsiness) were more frequent with paroxetine but mild and transient; no serious events occurred. The dropout rate was 14.4% (13\/90), and intention\u2010to\u2010treat analysis showed consistent findings with slightly attenuated effect sizes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot study, paroxetine 20\u2009mg\/day showed promise in reducing VMS and improving quality of life in Honduran women with surgical menopause, with acceptable tolerability. The high attrition rate underscores the need for larger trials to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71093","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:51:32Z","timestamp":1779457892000},"page":"779-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Paroxetine versus placebo for the management of vasomotor symptoms in surgical menopause: A pilot double\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2048-9195","authenticated-orcid":false,"given":"Heisell Gabriela","family":"\u00c1lvarez Castro","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidad Nacional Aut\u00f3noma de Honduras (UNAH)  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra Paola","family":"Romero Huete","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidad Nacional Aut\u00f3noma de Honduras (UNAH)  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00ed Emelda","family":"Bu Urbina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidad Nacional Aut\u00f3noma de Honduras (UNAH)  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2419-8020","authenticated-orcid":false,"given":"Arnold Reinieri","family":"Cambar\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Instituto Hondure\u00f1o de Seguridad Social (IHSS)  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0430-2474","authenticated-orcid":false,"given":"Ricardo Arturo","family":"Gutierrez\u2010Ramirez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universidad Nacional Aut\u00f3noma de Honduras (UNAH)  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-007-02095"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2024.103936"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.53853\/encr.11.1.853"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(24)00528-X"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.31434\/rms.v8i1.933"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1283-081X(24)49930-X"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"45","article-title":"Menopausia En Las Mujeres Que Asisten A La Consulta Externa De Ginecolog\u00eda Del Hospital Escuela","volume":"7","author":"Rodr\u00edguez S","year":"2022","journal-title":"Rev Med Post UNAH"},{"key":"e_1_2_10_9_1","unstructured":"BatulanZ BhimlaA HigginbothamA.6 enfermedades cr\u00f3nicas que afectan predominantemente a las mujeres de manera diferente.2024NLM Bookshelf.https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK607719\/"},{"key":"e_1_2_10_10_1","volume-title":"StatPearls","author":"Harper GH","year":"2024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.91a.23067"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1204163"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20230398"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20230398"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2021.17.2.133"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000210"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S282396"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55090554"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"430","article-title":"SSRIs vs. SNRIs for vasomotor symptoms of menopause","volume":"105","author":"Newhouser LM","year":"2022","journal-title":"Am Fam Physician"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71093","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71093","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:49:44Z","timestamp":1792172984000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1002\/ijgo.71093"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71093","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}