{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:26:36Z","timestamp":1789521996697,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pre\u2010eclampsia is a serious pregnancy\u2010related syndrome lacking accurate prognostic markers. MicroRNA\u2010210, overexpressed in the circulation of women with pre\u2010eclampsia, has recently emerged as a promising biomarker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis to evaluate the relationship between miR\u2010210 levels and pre\u2010eclampsia at different degrees of severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Search Strategy<\/jats:title>\n                    <jats:p>The study was prospectively registered on PROSPERO (CRD42024604698) and included a comprehensive systematic search of five databases conducted on November 21, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Selection Criteria, Data Collection and Analysis<\/jats:title>\n                    <jats:p>The included studies involved pregnant women with mild or severe pre\u2010eclampsia compared to normotensive controls, meeting guideline\u2010based diagnostic criteria and reporting circulating microRNA\u2010210. Precalculated effect sizes were pooled to obtain a weighted mean and 95% confidence interval (CI) for microRNA\u2010210\u2010fold increase. Subgroup analysis assessed pre\u2010eclampsia severity, using an inverse variance method in random\u2010effects meta\u2010analysis models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results<\/jats:title>\n                    <jats:p>\n                      Our search identified 776 records, of which seven were deemed eligible for analysis. The fold change values, reflecting the increase in microRNA\u2010210 levels between the control and pre\u2010eclamptic populations, were 3.33 (CI: 0.69\u20135.98;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200993%, CI: 88\u201396%) in the mild pre\u2010eclampsia group and 7.23 (CI: 2.27\u201312.18;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200998%, CI: 98\u201399%) in the severe pre\u2010eclampsia group, indicating a significant effect (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01) in the subgroup difference tests. The mean ratio of microRNA\u2010210\u2010fold change between the two severity groups was 2.05 (CI: 1.41\u20132.69;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200985%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), favoring the severe population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated microRNA\u2010210 levels are strongly associated with pre\u2010eclampsia severity at the time of diagnosis, with a consistent, significant stepwise increase from mild to severe disease. Whether miR\u2010210 holds predictive value earlier in pregnancy remains to be established in prospective studies with first\u2010trimester sampling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71145","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:48:51Z","timestamp":1782208131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MicroRNA<\/scp>\n                    \u2010210 level as a biomarker for pre\u2010eclampsia severity: A systematic review and meta\u2010analysis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0954-8884","authenticated-orcid":false,"given":"D\u00e1vid","family":"M\u00e1rai","sequence":"first","affiliation":[{"name":"Center for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Obstetrics and Gynecology Semmelweis University  Budapest 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