{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:52:35Z","timestamp":1781772755686,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82\u2009271\u2009697"],"award-info":[{"award-number":["82\u2009271\u2009697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82\u2009101\u2009768"],"award-info":[{"award-number":["82\u2009101\u2009768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine how different antiphospholipid antibody (aPL) profiles influence placental\u2010mediated adverse pregnancy outcomes (APOs) in women with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 245 pregnant women with SLE and 490 controls from a single center. Clinical features, immunologic markers and aPL profiles were analyzed. Logistic regression models were used to explore associations between antiphospholipid syndrome (APS), individual aPL subtypes, antibody burden and placental\u2010mediated APOs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Placental\u2010mediated APOs occurred more often in SLE pregnancies than in controls (27.8% vs. 9.8%). After adjustment, APS was not independently associated with APOs. Renal involvement, chronic hypertension and hypocomplementemia remained significant predictors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Among antibody types, lupus anticoagulant (LAC) showed the strongest association in univariate analysis, but the effect weakened in multivariable analysis. Women with multiple aPL positivity had a higher risk of placental complications, whereas single positivity showed little independent effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In SLE pregnancies, obstetric risk is not explained by APS alone. Antibody burden, especially multiple aPL positivity, together with renal disease, hypertension and complement levels appears more informative for assessing placental\u2010related risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71147","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:08:49Z","timestamp":1781770129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reassessing the role of antiphospholipid antibodies in placental\u2010mediated adverse pregnancy outcomes in systemic lupus erythematosus: A retrospective cohort study"],"prefix":"10.1002","author":[{"given":"Meng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"},{"name":"Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, International Centre for Reproductive Health (ICRH) Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Di","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"},{"name":"State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6247-9489","authenticated-orcid":false,"given":"Jiayue","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1016\/S2665-9913(24)00160-7","article-title":"Pregnancy outcome predictors in systemic lupus erythematosus: a systematic review and meta\u2010analysis","volume":"6","author":"Wind M","year":"2024","journal-title":"Lancet Rheumatol"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1080\/01443615.2023.2205513","article-title":"Maternal and fetal outcomes of SLE in pregnancy: a literature review","volume":"43","author":"Sangah AB","year":"2023","journal-title":"Journal of Obstetrics and Gynaecology"},{"issue":"13","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1177\/0961203318802016","article-title":"Pathogenic role of antiphospholipid antibodies: an update","volume":"27","author":"Fujieda 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