{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:19:25Z","timestamp":1783063165442,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While Cell Saver technology effectively reduces red blood cell transfusion in the perioperative setting, its impact on the need for pro\u2010hemostatic factors remains unclear. The use of Cell Saver could impact the requirements of pro\u2010hemostatic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study assesses whether the use of Cell Saver influences transfusion requirements for fresh frozen plasma, platelet concentrates, and fibrinogen in surgeries for placenta accreta spectrum (PAS) disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, single\u2010center, before\u2010and\u2010after study was conducted in a tertiary maternity hospital. Women undergoing surgery for PAS (cesarean delivery with conservative treatment or hysterectomy) were included. Two periods were compared: before (2013\u20132017, Period A) and after Cell Saver implementation (2019\u20132023, Period B), with a 1\u2010year washout (2018). The primary outcome was a composite criterion: transfusion of \u2265\u20093\u2009units of FFP (fresh frozen plasma) and\/or \u2265\u20091 unit of PC (platelet concentrates) and\/or \u2265\u20094\u2009g fibrinogen. Univariate and multivariable logistic regression analyses were conducted, with subgroup analyses in women undergoing hysterectomy and those with blood loss \u2265\u20092000\u2009mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 136 women (69 in Period A, 67 in Period B), Cell Saver was used in 86% of Period B cases (median volume: 769\u2009mL). The primary outcome occurred in 42% of Period A versus 52.2% of Period B (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.23). However, multivariable analysis showed lower odds of pro\u2010hemostatic transfusion with Cell Saver use (adjusted odds ratio 0.21; 95% confidence interval 0.06\u20130.77). In patients with \u2265\u20092000\u2009mL blood loss, the primary outcome was significantly less frequent in Period B (71.1% vs. 95.6%,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cell Saver use during PAS surgery is independently associated with reduced pro\u2010hemostatic transfusion, especially in cases with major bleeding, supporting its routine use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71181","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:57:12Z","timestamp":1783061832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Cell Saver technology on pro\u2010hemostatic factors transfusion in placenta accreta spectrum interventions: A 10\u2010year retrospective single\u2010center study"],"prefix":"10.1002","author":[{"given":"Ilan","family":"Levy","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Port\u2010Royal Maternity Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Vachette","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Port\u2010Royal Maternity Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Van Der Putten","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Port\u2010Royal Maternity, Cochin Hospital Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Chouteau","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Port\u2010Royal Maternity, Cochin Hospital Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Goffinet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Port\u2010Royal Maternity Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Port\u2010Royal Maternity, Cochin Hospital Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Girault","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Port\u2010Royal Maternity Universit\u00e9 Paris Cit\u00e9, APHP  Paris 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