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Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and psychological morbidity, and sexual health concerns. Therefore, interventions in POI\/EM represent some of the most actionable opportunities to reduce long\u2010term disability and promote healthy longevity. However, current approaches to hormone therapy (HT) in POI\/EM remain fragmented, delayed, and overly influenced by paradigms derived from older postmenopausal populations. We propose a shift toward a life\u2010course model of care. POI and EM should no longer be managed as variants of menopause at normal age but recognized as chronic endocrine conditions and sentinel events for accelerated aging in women. HT should be reframed as a hormonal replacement aimed at preventing long\u2010term disability. Timely initiation, adequate dosing, and long\u2010term continuation of HT should be considered foundational to POI\/EM care, alongside integrated preventive strategies. FIGO and IMS, therefore, call for a globally coordinated effort to strengthen awareness, professional education, and research on POI\/EM, and to ensure equitable access to multidisciplinary care, with the goal of improving women's health and supporting the long\u2010term sustainability of healthcare systems.<\/jats:p>","DOI":"10.1002\/ijgo.71217","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T07:02:31Z","timestamp":1787036551000},"page":"26-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hormone therapy (\n                    <scp>HT<\/scp>\n                    ) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint\n                    <scp>FIGO<\/scp>\n                    and\n                    <scp>IMS<\/scp>\n                    position paper"],"prefix":"10.1002","volume":"175","author":[{"given":"Chiara","family":"Benedetto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sant'anna University Hospital  Torino Italy"},{"name":"Department of Surgical Sciences University of Torino  Torino Italy"},{"name":"FIGO Committee on Women at Menopausal Age International Federation of Gynecology and Obstetrics (FIGO)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvarna S.","family":"Khadilkar","sequence":"additional","affiliation":[{"name":"FIGO Committee on Women at Menopausal Age International Federation of Gynecology and Obstetrics (FIGO)  London UK"},{"name":"Department of Obstetrics and Gynecology Bombay Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella E.","family":"Nappi","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"},{"name":"Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause IRCCS S. Matteo Foundation  Pavia Italy"},{"name":"Executive Committee of the International Menopause Society (IMS)  Totnes Devon UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea R.","family":"Genazzani","sequence":"additional","affiliation":[{"name":"FIGO Committee on Women at Menopausal Age International Federation of Gynecology and Obstetrics (FIGO)  London UK"},{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Frezet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sant'anna University Hospital  Torino Italy"},{"name":"Department of Surgical Sciences University of Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cucinella","sequence":"additional","affiliation":[{"name":"Research Center for Reproductive Medicine, Gynecological Endocrinology and Menopause IRCCS S. 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