{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:19:09Z","timestamp":1783664349200,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Copper intrauterine contraceptive devices (CuT\u2010375) are highly effective but also have frequent side effects like heavy menstrual bleeding (HMB). The present study was planned to evaluate the role of pre\u2010insertion uterine artery Doppler indices\u2014pulsatility index (PI) and resistance index (RI) in predicting the risk of HMB following insertion of CuT\u2010375.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective clinical study included 111 women who elected to use the CuT\u2010375, met predefined eligibility criteria, and completed 6\u2009months of follow\u2010up. Before device insertion, uterine artery Doppler assessment was performed to measure PI and RI. Following insertion, participants were categorized into two groups based on menstrual blood loss assessed through the pictorial blood assessment chart (PBAC): heavy menstrual bleeding (PBAC &gt;100;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951) and non\u2010heavy bleeding (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960). Receiver operating characteristic (ROC) curve analysis was used to determine the predictive performance of PI and RI for identifying women at risk of intrauterine contraceptive device (IUCD)\u2010related HMB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Uterine artery PI value \u22642.15 showed high predictive accuracy for heavy menstrual bleeding, yielding a sensitivity of 100%, specificity of 90%, and an AUC of 0.991 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). RI value \u22640.775 demonstrated a sensitivity of 82.35%, specificity of 100%, and an AUC of 0.966 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Both parameters exhibited a strong association\u2010lower baseline Doppler indices had increased risk of significant post\u2010insertion bleeding. Women with PI and RI values below these thresholds were most likely to experience HMB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre\u2010insertion uterine artery Doppler evaluation serves as a reliable predictor of HMB following CuT\u2010375 insertion. Incorporating these Doppler indices into routine pre\u2010contraceptive assessment may improve patient selection and counseling, potentially reducing IUCD\u2010related complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71223","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:07:47Z","timestamp":1783663667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of uterine artery doppler indices in prediction of the risk of heavy menstrual bleeding following copper intrauterine contraceptive device (\n                    <scp>CuT<\/scp>\n                    \u2010375) insertion"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0565-8107","authenticated-orcid":false,"given":"Dakshika","family":"Lochan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Dr Baba Saheb Ambedkar Medical College and Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1161-9883","authenticated-orcid":false,"given":"Neeru","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Dr Baba Saheb Ambedkar Medical College and Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupa","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Family Planning Unit Dr Baba Saheb Ambedkar Medical College and Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0088-374X","authenticated-orcid":false,"given":"Rishabh","family":"Kochar","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine Apex Hospital  Bikaner Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Key data | UNICEF India.2024.https:\/\/www.unicef.org\/india\/key\u2010data"},{"key":"e_1_2_9_3_1","unstructured":"Status of IMR and MMR in India.2024.https:\/\/pib.gov.in\/pib.gov.in\/Pressreleaseshare.aspx?PRID=1796436"},{"key":"e_1_2_9_4_1","unstructured":"Report of a WHO technical consultation on birth spacing: Geneva Switzerland 13\u201315 June 2005.2024.https:\/\/www.who.int\/publications\/i\/item\/WHO\u2010RHR\u201007.1"},{"key":"e_1_2_9_5_1","unstructured":"BordaM.Family planning needs during the extended postpartum period in India. Access family planning initiative brief.2009."},{"key":"e_1_2_9_6_1","unstructured":"NFHS\u20105_Phase\u2010II_0.pdf.2024.https:\/\/mohfw.gov.in\/sites\/default\/files\/NFHS\u20105_Phase\u2010II_0.pdf"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2008.11.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20221811"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.05.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.20349"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-020-00345-5"},{"key":"e_1_2_9_12_1","volume-title":"World Family Planning 2022: Meeting the Changing Needs for Family Planning: Contraceptive Use by Age and Method","year":"2022"},{"issue":"13","key":"e_1_2_9_13_1","first-page":"63","article-title":"Uterine artery Doppler as predictor of side effects in copper intrauterine device users","volume":"13","author":"Mohamed RS","year":"2015","journal-title":"Al\u2010Azhar Assiut Med J"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31828b63a0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-023-00357-8"},{"key":"e_1_2_9_16_1","unstructured":"IUCD_Manual_English.pdf.2025.https:\/\/nhm.gov.in\/New_Updates_2018\/NHM_Components\/RMNCHA\/Family_planning\/Schemes_&_Guidelines\/IUCD\/IUCD_Manual_English.pdf"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2019.07.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10006-1257"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.21276\/obgyn.20252024.11.1.19"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.21608\/bjas.2023.200296.1119"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.01.046"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:07:48Z","timestamp":1783663668000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":20,"alternative-id":["10.1002\/ijgo.71223"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71223","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,9]]},"assertion":[{"value":"2026-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijgo.71223"}}