{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:47:44Z","timestamp":1785761264620,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020771","name":"Natural Science Foundation for Young Scientists of Shanxi Province","doi-asserted-by":"publisher","award":["82204396"],"award-info":[{"award-number":["82204396"]}],"id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association of a history of hypertensive disorders of pregnancy (HDP) and a higher risk of cardiovascular disease using a sex\u2010specific cohort study, bidirectional two\u2010sample Mendelian randomization (MR), and in\u00a0vitro experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multivariable logistic regression was used to assess the association between thyroid function and HDP. We performed bidirectional two\u2010sample MR using summary statistics from genome\u2010wide association study meta\u2010analyses, FinnGen, and UKB to assess the potential association between thyroid function and HDP. In\u00a0vitro experiments were conducted to explore the potential biologic mechanisms underlying the observed association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009119\u2009668), hyperthyroidism was associated with higher HDP risk (odds ratio [OR] 1.79, 95% confidfence interval [CI] 1.10\u20132.92,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.020; fully adjusted for confounders). MR identified a potential association of genetically predicted thyroid\u2010stimulating hormone (TSH) on HDP (OR 0.92, 95% CI 0.85\u20130.99,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.018), but no evidence was found to support a causal effect of hypothyroidism, hyperthyroidism, or free thyroxine on HDP. Reverse MR indicated that genetically predicted pre\u2010eclampsia was associated with elevated TSH levels (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      0.12, 95% CI 0.05\u20130.19,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). In\u00a0vitro experiments confirmed and provided supportive mechanistic evidence that TSH may directly induce vascular endothelial injury and dysfunction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates an independent observational association between hyperthyroidism and an increased risk of HDP, and provides supportive genetic evidence for a possible bidirectional association between genetically predicted TSH and HDP. These findings highlight TSH as a potential biomarker for HDP risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71255","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:55:28Z","timestamp":1785758128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thyroid function and hypertensive disorders of pregnancy: Insights from a sex\u2010specific cohort study, Mendelian randomization, and experimental validation"],"prefix":"10.1002","author":[{"given":"Yu","family":"He","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeshen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial 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