{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:23:58Z","timestamp":1787063038603,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To investigate the correlation between the C\u2010reactive protein\u2010Albumin\u2010Lymphocyte (CALLY) index, Systemic Immune\u2010inflammation Index (SII), and Aggregate Systemic Inflammation Index (AISI), which are comprehensive biomarkers of inflammatory status, and female stress urinary incontinence (SUI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Based on cross\u2010sectional study data from the 2005\u20132010 National Health and Nutrition Examination Survey (NHANES), univariate analyses of continuous variables and categorical variables were performed using\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, linear regression, and\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      tests. Associations between CALLY index, SII, AISI, and SUI were further examined through weighted multivariate logistic regression and subgroup analyses. Restricted cubic splines (RCS) were employed to assess potential nonlinear relationships between inflammatory markers and SUI risk. Subgroup analysis indicated a consistent relationship among CALLY index, SII, and SUI across the majority of subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 7144 women were included. A higher CALLY index was associated with fewer SUI patients, demonstrating a protective effect. Conversely, a greater AISI was associated with an increase in SUI patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). In all three models, CALLY index showed a significant inverse correlation with SUI risk (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas AISI demonstrated a positive correlation with SUI (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Receiver operating characteristics curve analysis suggested a nonlinear relationship between CALLY index, AISI, and SUI. Subgroup analysis indicated a consistent association among CALLY index, AISI, and SUI in most subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that an elevated CALLY index is a protective factor for SUI, whereas an elevated AISI represents a risk factor. The CALLY index exhibits greater stability compared with other inflammatory markers (SII, AISI), though prospective studies are warranted to validate these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71290","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:24:12Z","timestamp":1787059452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between the C\u2010reactive protein\u2010albumin\u2010lymphocyte (\n                    <scp>CALLY<\/scp>\n                    ) index and stress urinary incontinence in women: A population\u2010based study"],"prefix":"10.1002","author":[{"given":"Xufeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Radiology Yuyao Hospital of Traditional Chinese Medicine  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Gynecology Ningbo Hospital of Integrated T traditional Chinese and Western Medicine  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-3048","authenticated-orcid":false,"given":"Hangyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics The Affiliated Lihuili Hospital of Ningbo University  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.maturitas.2017.12.008","article-title":"Management of female stress urinary incontinence: A care pathway and update","volume":"109","author":"Giampiero C","year":"2018","journal-title":"Maturitas"},{"key":"e_1_2_10_3_1","volume-title":"StatPearls","author":"Lugo T","year":"2026"},{"key":"e_1_2_10_4_1","first-page":"1871","article-title":"Impact of female stress urinary incontinence on quality of life, mental health, work limitation, and healthcare seeking in China, Taiwan, and South Korea (LUTS Asia): results from a cross\u2010sectional, population\u2010based study","volume":"14","author":"Po\u2010Ming C","year":"2023","journal-title":"Int J Women's Health"},{"issue":"12","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ejsc.12121","article-title":"Up for the tackle? 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