{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:08:34Z","timestamp":1789031314343,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Induction of labor (IOL) is a common obstetric procedure performed when continuation of pregnancy poses maternal or fetal risks. Prostaglandin E\n                      <jats:sub>2<\/jats:sub>\n                      (PGE\n                      <jats:sub>2<\/jats:sub>\n                      ) is widely used for cervical ripening and induction. This study assessed the success rate of PGE\n                      <jats:sub>2<\/jats:sub>\n                      \u2010induced labor and identified obstetric predictors of failed induction and cesarean delivery at a tertiary center in Riyadh.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective cross\u2010sectional study included 1303 women who underwent IOL with PGE\n                      <jats:sub>2<\/jats:sub>\n                      (tablet or pessary) at the Women's Health Hospital, National Guard Health Affairs, Riyadh, during 2023. Maternal characteristics, obstetric factors, and induction\u2010related variables were analyzed using descriptive and inferential statistics. Logistic regression was applied to determine independent predictors of failed induction and cesarean section, with statistical significance set at\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall success rate of PGE\n                      <jats:sub>2<\/jats:sub>\n                      induction was 74.2%, consistent with global benchmarks. The vaginal tablet demonstrated higher effectiveness (80.6%) compared with the pessary (59.4%). Advanced maternal age, pre\u2010eclampsia, and type 1 diabetes significantly increased the likelihood of failed induction and cesarean delivery. Intrapartum factors, particularly nonreassuring cardiotocography and inadequate cervical response, were strong determinants of cesarean section.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      PGE\n                      <jats:sub>2<\/jats:sub>\n                      was effective for induction of labor in this cohort. The vaginal tablet was associated with a higher observed vaginal delivery rate than the pessary; however, this finding should be interpreted cautiously because formulation selection was not randomized and was based on availability. Individualized assessment, method selection, and fetal monitoring remain important. Women with relevant medical comorbidities should be counseled regarding their increased risk of cesarean delivery. Further prospective multicenter studies comparing efficacy, maternal safety, and neonatal outcomes are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71295","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:26:12Z","timestamp":1789028772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends of induction of labor with success rates: Experience of a tertiary care center"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7679-0761","authenticated-orcid":false,"given":"Feras","family":"Alkharouf","sequence":"first","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"Department of Maternal\u2013Fetal Medicine Women's Health Hospital, National Guard Health Affairs  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-2946","authenticated-orcid":false,"given":"Nada F.","family":"Alqudaibi","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"Department of Obstetrics and Gynecology King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aminah A.","family":"Alhamdan","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"Department of Obstetrics and Gynecology King Saud Medical City  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd A.","family":"Alomar","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud bin Abdulaziz University for Health Sciences  Riyadh Saudi Arabia"},{"name":"Department of General Pediatrics King Abdullah Specialized Children's Hospital, National Guard Health Affairs  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danah I.","family":"Alnahari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Women's Health Hospital, National Guard Health Affairs  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls [Internet]","author":"Gill P","year":"2023"},{"key":"e_1_2_11_3_1","volume-title":"StatPearls [Internet]","author":"Xi M","year":"2023"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.12255"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xagr.2022.100099"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13794"},{"key":"e_1_2_11_7_1","volume-title":"StatPearls [Internet]","author":"Wormer KC","year":"2023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-013-0486-z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001778"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(91)90289-h"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349209009919"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70265-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.130925"},{"key":"e_1_2_11_14_1","first-page":"1","article-title":"Maternal and neonatal outcomes of elective induction of labor","volume":"176","author":"Caughey AB","year":"2009","journal-title":"Evid Rep Technol Assess"},{"issue":"1","key":"e_1_2_11_15_1","first-page":"1","article-title":"Births: final data for 2016","volume":"67","author":"Martin JA","year":"2018","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331024"}],"container-title":["International Journal of Gynecology &amp; 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