{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:07:23Z","timestamp":1788941243826,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFAA026276"],"award-info":[{"award-number":["2023GXNSFAA026276"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology & Obste"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Ovarian cancer, being the most lethal female\u2010specific cancers, presents a significant health threat to midlife women undergoing the menopause and perimenopause transition. This study aims to investigate the patterns and trends of ovarian cancer among this population from 1990 to 2021.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using 1990\u20132021 data, we calculated age\u2010standardized rates (ASRs) and estimated annual percentage changes (EAPCs) for ovarian cancer among midlife women, including those aged 40\u201359\u2009years (encompassing the perimenopausal transition) and those aged 45\u201354\u2009years (the typical menopausal age range). Temporal trends in incidence, mortality, prevalence, and disability\u2010adjusted life years (DALYs) were analyzed using joinpoint regression to identify significant inflection points, age\u2010period\u2010cohort modeling to estimate independent effects of age, period, and birth cohort, and Bayesian age\u2010period\u2010cohort projections to forecast disease burden up to 2035.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n From 1990 to 2021, new ovarian cancer cases among women aged 45\u201354\u2009years increased by 92.6% and among those aged 40\u201359\u2009years by 90.4%, while ASRs declined (incidence EAPC: \u22120.46 and \u22120.42, respectively). An inverted U\u2010shaped relationship between socio\u2010demographic index (SDI) and burden was observed: ASRs decreased in high\u2010SDI regions but increased in low\u2013middle SDI areas. The 55\u201359\u2010year age group consistently carried the highest burden, accounting for approximately 35% of incident cases and 40% of deaths among midlife women. Cohort effects showed a progressive decline in risk for women born after 1956. Bayesian projections predict continued global increases in new cases, deaths, and DALYs from 2022 to 2035, with rising ASRs for incidence and prevalence.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This pioneering analysis of Global Burden of Disease Study 2021 data reveals persistent socioeconomic disparities, distinct age\u2010specific patterns (peak burden at 55\u201359\u2009years), and ongoing epidemiological transitions in ovarian cancer among midlife women. Based on our findings, potential public health priorities could include sustaining recent progress in high\u2010SDI regions to maintain declining trends and enhancing diagnostic capacity and risk\u2010factor management in low\u2013middle SDI settings to counter rising burden. These population\u2010level patterns might further research and health policy planning tailored to regional sociodemographic contexts.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ijgo.71302","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:55:15Z","timestamp":1788940515000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evolving dynamics of ovarian cancer in midlife women: A\u00a0three\u2010decade age\u2010period\u2010cohort study"],"prefix":"10.1002","author":[{"given":"Rui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyan","family":"Yue","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development, Shanghai Key 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