{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:00:33Z","timestamp":1789992033709,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Several investigations have reported on the increased risk of meningioma following depot medroxyprogesterone acetate (DMPA) treatment. An extensive PubMed search was conducted evaluate systematic reviews, propensity\u2010matched studies and case\u2013control studies on the topics of DMPA use and meningioma risk from 2018\u20132026. Primarily, the studies have reported that the risk of a meningioma is exacerbated by prolonged use of DMPA, which confers sustained and higher systemic exposure to progestin. Despite the documented risk of meningioma from case\u2013control studies, the actual number of meningioma cases associated with DMPA is extremely low. While patients should be aware of the risks associated with enduring use of DMPA, one should also consider the therapeutic benefits, namely the drug's use as a treatment for endometriosis, dysmenorrhea and the secondary effects of reducing the risk for endometrial and ovarian cancers. Additional research that evaluates the clinical risk\u2013benefit ratio associated with DMPA use is warranted.<\/jats:p>","DOI":"10.1002\/ijgo.71361","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:08:37Z","timestamp":1789988917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depot medroxyprogesterone acetate and the risk for developing an intracranial meningioma"],"prefix":"10.1002","author":[{"given":"John P.","family":"Micha","sequence":"first","affiliation":[{"name":"Department of Breast and Gynecologic Oncology The Women's Cancer Research Foundation  Laguna Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy D.","family":"Bohart","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Oso Home Care, Inc.  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Gorman","sequence":"additional","affiliation":[{"name":"Department of Neurology Arizona Neurology Associates  Glendale Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-2105","authenticated-orcid":false,"given":"Bram H.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Breast and Gynecologic Oncology The Women's Cancer Research Foundation  Laguna Beach California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"NSFG\u2014Listing C\u2014Key Statistics from the National Survey of Family Growth. Accessed December 17 2024.https:\/\/www.cdc.gov\/nchs\/nsfg\/key_statistics\/c\u2010keystat.htm#contraception"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijpvm.IJPVM_163_19"},{"key":"e_1_2_10_4_1","first-page":"381","article-title":"Pharmacokinetics of depot medroxyprogesterone acetate contraception","volume":"41","author":"Mishell DR","year":"1996","journal-title":"J Reprod Med"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.3011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-078078"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16193362"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad149"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030980"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/cns-2021-0003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.6.JNS11129"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2013.06.008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/026886900417388"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004321"},{"key":"e_1_2_10_15_1","unstructured":"FDA.Highlights of Prescribing Information.2025.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2025\/020246s074lbl021583s045lbl.pdf"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2026.103791"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaf228"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1166\/asl.2017.9121"},{"key":"e_1_2_10_19_1","first-page":"69","article-title":"Depo Provera. Position paper on clinical use, effectiveness and side effects","volume":"25","author":"Bigrigg A","year":"1999","journal-title":"Br J Fam Plann"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003089"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S28872"},{"key":"e_1_2_10_22_1","first-page":"419","article-title":"Depot medroxyprogesterone acetate contraception and the risk of breast and gynecologic cancer","volume":"41","author":"Kaunitz AM","year":"1996","journal-title":"J Reprod Med"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(97)00156-X"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1355"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14846"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20153822"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88742-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01520.x"},{"key":"e_1_2_10_29_1","article-title":"Skull base meningiomas as part of a novel meningioma syndrome associated with chronic depot medroxyprogesterone acetate use","volume":"84","author":"Abou\u2010Al\u2010Shaar H","year":"2023","journal-title":"J Neurol Surg B Skull Base"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32070401"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7164.1014"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40834-025-00380-5"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2024.109570"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:08:40Z","timestamp":1789988920000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":32,"alternative-id":["10.1002\/ijgo.71361"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71361","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2026-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijgo.71361"}}