{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:54:33Z","timestamp":1791186873743,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to describe and compare maternal infectious morbidity, microbiological findings, and neonatal outcomes among pregnancies with early (&lt;34\u2009weeks) and late (34\u2009+\u20090\u201336\u2009+\u20096\u2009weeks) prelabor rupture of membranes (PPROM) managed expectantly at a single tertiary referral center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010center retrospective cohort study included consecutive singleton pregnancies complicated by PPROM at \u226524\u2009weeks of gestation and managed expectantly at Galilee Medical Center, a university\u2010affiliated tertiary referral center in Nahariya, Israel, between August 2017 and May 2024. Patients were categorized according to gestational age at membrane rupture into early (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u2009136) and late (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u2009548) PPROM. Expectant management was applied using a 7\u2010day antibiotic regimen (ampicillin\u2010based until March 2023, followed by cefuroxime\u2010based prophylaxis). Patients with active labor or clinical infection at admission were excluded. Primary outcomes were clinical chorioamnionitis and early\u2010onset neonatal sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Late PPROM was associated with lower rates of postpartum maternal infectious morbidity than early PPROM, including lower rates of intrapartum fever (2.6% vs. 6.6%), postpartum fever (0.2% vs. 2.9%), and surgical site infection (0.8% vs. 12.3%). In exploratory adjusted analysis, cefuroxime\u2010based prophylaxis was associated with lower observed odds of clinical chorioamnionitis compared with ampicillin\u2010based prophylaxis, whereas late versus early PPROM was not independently associated with clinical chorioamnionitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among pregnancies with PPROM managed expectantly, late PPROM was associated with lower observed rates of maternal infectious morbidity compared with early PPROM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71394","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:32:09Z","timestamp":1791185529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infectious morbidity and microbiological findings in early and late preterm prelabor rupture of membranes managed expectantly"],"prefix":"10.1002","author":[{"given":"Raneen","family":"Abu Shqara","sequence":"first","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Domfrocht","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarden","family":"Perez","sequence":"additional","affiliation":[{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vered Fleisher","family":"Sheffer","sequence":"additional","affiliation":[{"name":"Department of Neonatal Intensive Care Galilee Medical Center  Nahariya Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-3234","authenticated-orcid":false,"given":"Maya","family":"Frank Wolf","sequence":"additional","affiliation":[{"name":"Raya Strauss Wing of Obstetrics and Gynecology Galilee Medical Center  Nahariya Israel"},{"name":"Azrieli Faculty of Medicine Bar\u2010Ilan University  Safed Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003700"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.03.003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.36615"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002447"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2024.101563"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004735.PUB4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00724-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15803"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJOGRB.2019.02.021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JOGC.2022.08.014\/ASSET\/38395479-FA30-4D30-9661-105944E75D00\/MAIN.ASSETS\/GR1.SML"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.100900"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1516783\/SUPPL_FILE\/NEJMOA1516783_DISCLOSURES.PDF"},{"key":"e_1_2_11_15_1","unstructured":"Early\u2010Onset Neonatal Sepsis Surveillance and Trends | ABCs | CDC. n.d.https:\/\/www.cdc.gov\/abcs\/reports\/neonatal\u2010sepsis.html"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2019.11.020"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PMED.1001208"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14899"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-025-08030-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.0593"}],"container-title":["International Journal of Gynecology &amp; 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