{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:57:23Z","timestamp":1792151843303,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluates the fetal adrenal gland microvascular index (MVI) and adrenal volume in late\u2010onset fetal growth restriction (FGR) using MV\u2010Flow and three\u2010dimensional Extended Imaging Virtual Organ Computer\u2010Aided Analysis and assesses their associations with neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study at a single tertiary center (July 2024\u2013August 2025) included 58 fetuses with late\u2010onset FGR and 65 healthy controls. FGR was defined as abdominal circumference or estimated fetal weight &lt;3rd percentile or 3\u201310th percentile with Doppler abnormalities. Fetal adrenal MVI (microvascular perfusion relative to organ size) and adrenal volume were measured during routine ultrasound. Group comparisons, logistic regression, receiver operating characteristic analyses, and correlation analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fetal adrenal MVI was significantly higher in the FGR group (38.9% vs. 23.1%,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.001). MVI was independently associated with FGR (odds ratio 1.175, 95% confidence interval [CI] 1.108\u20131.247,\n                      <jats:italic>P\u2009&lt;<\/jats:italic>\n                      \u20090.001). MVI showed good discriminative ability for FGR (area under the receive operator characteristic curve\u2009=\u20090.876, 95% CI 0.815\u20130.937), with a cutoff of 25.3% (94.8% sensitivity, 64.6% specificity). Although adrenal volume was lower in the FGR group (4.37 vs. 5.50\u2009cm\n                      <jats:sup>\n                        <jats:bold>3<\/jats:bold>\n                      <\/jats:sup>\n                      ,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.016), this difference disappeared after normalization to estimated fetal weight (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.149) and abdominal circumference (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.558). Lower adrenal volume was associated with neonatal intensive care unit admission independently of gestational age and birth weight (partial\n                      <jats:italic>r\u2009=<\/jats:italic>\n                      \u2009\u22120.252,\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.010).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fetal adrenal glands show reduced absolute volume but increased microvascular perfusion in FGR cases. Adrenal MVI is a size independent marker of late\u2010onset FGR, whereas reduced adrenal volumes largely reflects smaller fetal size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71398","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:34:05Z","timestamp":1792150445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fetal adrenal microvascular index and adrenal volume in late\u2010onset fetal growth restriction: A prospective observational study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-7324","authenticated-orcid":false,"given":"Ay\u015fe G\u00fcl\u00e7in","family":"Ba\u015ftemur","sequence":"first","affiliation":[{"name":"Perinatology Division, Department of Obstetrics and Gynecology Eski\u015fehir City Hospital  Eski\u015fehir 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