{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:48:33Z","timestamp":1791805713361,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the associations of the C\u2010reactive protein\u2010to\u2010albumin ratio (CAR index) and the albumin\u2013bilirubin (ALBI) score with latency duration and adverse perinatal outcomes among patients with preterm premature rupture of membranes (PPROM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      This was a single\u2010center, retrospective study conducted at a tertiary care center. This study included 218 singleton pregnancies followed by a diagnosis of PPROM before 34\u2009weeks of gestation between January 2022 and December 2025. Patients were divided into three groups according to the latency period: delivery within the first 48\u2009h (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200992, 42%\u2014Group 1), delivery between 48\u2009h and 7\u2009days (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200956, 25.7%\u2014Group 2), and delivery after 7\u2009days (\n                      <jats:italic>n\u2009=<\/jats:italic>\n                      \u200970, 32.1%\u2014Group 3). First, the associations of the CAR index and ALBI score with latency period were evaluated across all three groups. Subsequently, the associations of the CAR index and ALBI score with neonatal outcomes were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The CAR index was significantly higher in Groups 1 and 2 than in Group 3 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). The CAR index showed discriminatory ability for delivery within 48\u2009h and within 7\u2009days, with sensitivities of 82.3% and 66.2%, respectively. In subgroup analysis, a higher maternal ALBI score was significantly associated with neonatal umbilical artery pH &lt;7.20 and showed discriminatory ability for identifying this outcome, with a sensitivity of 62.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with PPROM, the CAR index was associated with shorter latency and showed discriminatory ability for delivery within the first 48\u2009h and within the first 7\u2009days, whereas a higher ALBI score was significantly associated with neonatal umbilical artery pH &lt;7.20.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71400","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:20:16Z","timestamp":1791804016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship of the C\u2010reactive protein\/albumin ratio and the albumin\u2010bilirubin score with latency period and perinatal outcomes in preterm premature rupture of membranes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8143-5722","authenticated-orcid":false,"given":"Al\u0131","family":"C\u0131t\u0131rke","sequence":"first","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology Turkish Ministry of Health, Ankara City Hospital  Ankara 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Ministry of Health, Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0331-952X","authenticated-orcid":false,"given":"Salim","family":"Erkaya","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-9048","authenticated-orcid":false,"given":"Dilek","family":"Sah\u0131n","sequence":"additional","affiliation":[{"name":"Division of Perinatology, Department of Obstetrics and Gynecology University of Health Sciences, Turkish Ministry of Health, Ankara City Hospital  Ankara 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