{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:49:09Z","timestamp":1791614949637,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective of this study is to compare the fetal caval aortic (IVC\/Ao) index and left brachiocephalic vein (LBCV) diameter between pregnancies with preeclampsia (PE) and healthy controls. The study also assesses their association with disease severity and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective case\u2013control study, 60 pregnancies complicated by PE were compared with 60 gestational age\u2010matched healthy controls. The fetal IVC\/Ao index, LBCV diameter, Doppler parameters, and perinatal outcomes were assessed. Subgroup analyses in the PE group considered admission blood pressure, symptoms, proteinuria, and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The PE group had a lower IVC\/Ao index and larger LBCV diameter (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.043 and\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.025, respectively). The umbilical artery pulsatility index was higher (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.008), and the cerebroplacental ratio was lower (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.005) in PE. Smaller ascending aorta diameter was noted in severe hypertension (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.042), and the LBCV diameter was greater in symptomatic cases (\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.007). Proteinuria \u2265+2 was associated with earlier delivery (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014) and lower birth weight (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &lt;\u20090.001). Neonates admitted to the neonatal intensive care (NICU) had lower fetal inferior vena cava (IVC) diameters and lower IVC\/Ao indices. An IVC\/Ao index cutoff of 0.79 was associated with NICU admission, demonstrating moderate discriminatory performance (sensitivity 72.2%, specificity 73.8%, area under the curve\u2009=\u20090.762; 95% confidence interval 0.61\u20130.90;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fetuses of PE pregnancies had decreased IVC\/Ao index and enlarged LBCV diameter, potentially linked to impaired fetal hemodynamics. The IVC\/Ao index might help identify pregnancies complicated by PE that are at increased risk of NICU admission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71406","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:15:26Z","timestamp":1791612926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessing fetal circulatory alterations in preeclampsia: The role of caval aortic index and left brachiocephalic vein diameter"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-8312","authenticated-orcid":false,"given":"Gulcan","family":"Okutucu","sequence":"first","affiliation":[{"name":"Division of Perinatal Medicine, Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital  Ankara 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