{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:38:32Z","timestamp":1792481912635,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2024J08311"],"award-info":[{"award-number":["2024J08311"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2024J011351"],"award-info":[{"award-number":["2024J011351"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Endometriosis is a chronic inflammatory disease, with inflammation relating to pathogenesis and staging. We compared inflammatory indices and clinical characteristics between patients with ovarian endometriomas and those with benign ovarian tumors to evaluate their diagnostic value and identify affordable blood markers for diagnosis and staging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective single\u2010center case\u2013control study included 645 patients having laparoscopic surgery between January 1, 2020 and December 31, 2024: 372 with endometriosis and 273 controls with benign ovarian teratomas. Blood parameters and clinical characteristics were compared with Mann\u2013Whitney U and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. Independent risk factors for endometrioma and staging were evaluated using binary logistic regression. Predictive efficacy was assessed via receiver operating characteristic curves. Relationships between cancer antigen 125 (CA\u2010125) and hematologic parameters were determined with correlation analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with controls, patients with endometrioma had higher platelet\u2010to\u2010lymphocyte (PLR), neutrophil\u2010to\u2010lymphocyte (NLR)\u2009\u00d7\u2009CA\u2010125, and monocyte\u2010to\u2010lymphocyte ratios (MLR)\u2009\u00d7\u2009CA\u2010125, PLR\u2009\u00d7\u2009CA\u2010125, and CA\u2010125. Patients with endometrioma had more pelvic pain, larger cysts, and fewer pregnancies than controls. Higher CA\u2010125 and visual analog scale (VAS) scores occurred with endometriomas. Patients with stage IV had higher platelet counts, NLR\u2009\u00d7\u2009CA\u2010125, MLR\u2009\u00d7\u2009CA\u2010125, PLR\u2009\u00d7\u2009CA\u2010125, and CA\u2010125 levels than Stage III. Preoperative bilateral endometriomas and elevated CA\u2010125 were independent risk factors for Stage IV. CA\u2010125 was positively correlated with PLR, cyst diameter, cyst area, VAS score, and bilateral endometriomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The staging system is important\u00a0for assessing endometrial lesions, although it may not reflect the level of inflammatory activity. For patients with dysmenorrhea or pelvic pain, elevated CA\u2010125 demonstrated superior diagnostic value for ovarian endometrioma compared with PLR\u2009\u00d7\u2009CA\u2010125, and could serve as a simple, cost\u2010effective, and efficient assessment tools, providing information regarding endometriosis to inform clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71444","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:43:22Z","timestamp":1792478602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the diagnostic value of\n                    <scp>PLR<\/scp>\n                    and related hematologic parameters combined with\n                    <scp>CA<\/scp>\n                    \u2010125 for endometriomas"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-8542","authenticated-orcid":false,"given":"Pingping","family":"Su","sequence":"first","affiliation":[{"name":"Department of Gynecology, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenhong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Jinjiang Hospital Fujian Branch of Shanghai Sixth People's Hospital  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Women and Children's Hospital, School of Medicine Xiamen University  Xiamen Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"issue":"10276","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor HS","year":"2021","journal-title":"Lancet (London, England)"},{"issue":"5","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","author":"American Society For Reproductive Medicine","year":"1997","journal-title":"Fertil Steril"},{"issue":"11","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"19384","DOI":"10.1002\/jcp.28666","article-title":"The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: basic science and new insights based on gene expression","volume":"234","author":"Samimi M","year":"2019","journal-title":"J Cell Physiol"},{"issue":"19","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910554","article-title":"Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature)","volume":"22","author":"Smolarz B","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"7","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.7150\/thno.55241","article-title":"Ovarian hormones\u2010autophagy\u2010immunity axis in menstruation and endometriosis","volume":"11","author":"Shen H\u2010H","year":"2021","journal-title":"Theranostics"},{"issue":"11","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s00018-019-03056-x","article-title":"Anti\u2010inflammatory cytokines in endometriosis","volume":"76","author":"Zhou W\u2010J","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"e_1_2_12_8_1","unstructured":"AllaireC BedaiwyMA YongPJ.Diagnosis and management of endometriosis."},{"issue":"4","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/0167482X.2016.1244185","article-title":"Impact of endometriosis on quality of life and psychological well\u2010being","volume":"38","author":"Vitale SG","year":"2017","journal-title":"J Psychosom Obstet Gynecol"},{"issue":"2","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/0167482X.2019.1659775","article-title":"An overview on the relationship between endometriosis and infertility: the impact on sexuality and psychological well\u2010being","volume":"41","author":"La Rosa VL","year":"2020","journal-title":"J Psychosom Obstet Gynecol"},{"issue":"19","key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1097\/CM9.0000000000001063","article-title":"Current biomarkers for the detection of endometriosis","volume":"133","author":"Tian Z","year":"2020","journal-title":"Chin Med J"},{"issue":"11","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1111\/1471-0528.14055","article-title":"Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta\u2010analysis","volume":"123","author":"Hirsch M","year":"2016","journal-title":"BJOG"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bpobgyn.2018.01.006","article-title":"Pathogenesis of endometriosis: interaction between endocrine and inflammatory pathways","volume":"50","author":"Patel BG","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-069493","article-title":"How to diagnose COVID\u201019 in family practice? Usability of complete blood count as a COVID\u201019 diagnostic tool: a cross\u2010sectional study in Turkey","volume":"13","author":"Bayraktar M","year":"2023","journal-title":"BMJ Open"},{"issue":"9","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.3390\/healthcare10091780","article-title":"The cost\u2010effectiveness of requesting a complete blood count (CBC) in the management of COVID\u201019 in Saudi Arabia","volume":"10","author":"Sayed AA","year":"2022","journal-title":"Healthcare (Basel)"},{"issue":"17","key":"e_1_2_12_16_1","article-title":"Back to basics: the diagnostic value of a complete blood count in the clinical management of COVID\u201019","volume":"14","author":"Sayed AA","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.61622\/rbgo\/2024rbgo84","article-title":"Systemic inflammatory indices as a non\u2010invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy","volume":"46","author":"Sabra ASIM","year":"2024","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"3","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jmig.2013.06.003","article-title":"Noninvasive diagnosis of moderate to severe endometriosis: the platelet\u2010lymphocyte ratio cannot Be a Neoadjuvant biomarker for serum cancer antigen 125","volume":"22","author":"Yang H","year":"2015","journal-title":"J Minim Invasive Gynecol"},{"issue":"7","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1080\/01443615.2020.1845634","article-title":"Evaluating hematological parameters in women with endometriosis","volume":"41","author":"Moini A","year":"2021","journal-title":"J Obstet Gynaecol"},{"issue":"4","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.18632\/oncotarget.12577","article-title":"Implications of immune dysfunction on endometriosis associated infertility","volume":"8","author":"Miller JE","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.896152","article-title":"Platelet\u2010to\u2010lymphocyte ratio and CA125 level as a combined biomarker for diagnosing endometriosis and predicting pelvic adhesion severity","volume":"12","author":"Guo C","year":"2022","journal-title":"Front Oncol"},{"issue":"2","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1161\/CIRCRESAHA.117.310795","article-title":"Circulating platelets as mediators of immunity, inflammation, and thrombosis","volume":"122","author":"Koupenova M","year":"2018","journal-title":"Circ Res"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2147\/TCRM.S232849","article-title":"Systemic inflammatory response markers associated with infertility and Endometrioma or uterine leiomyoma in endometriosis","volume":"16","author":"Jing X","year":"2020","journal-title":"Ther Clin Risk Manag"},{"issue":"4","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5152\/jtgga.2013.55452","article-title":"Evaluation of mean platelet volume, neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio in advanced stage endometriosis with endometrioma","volume":"14","author":"Yavuzcan A","year":"2013","journal-title":"J Turk Ger Gynecol Assoc"},{"issue":"1","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm14010149","article-title":"The role of inflammatory markers NLR and PLR in predicting pelvic pain in endometriosis","volume":"14","author":"Gorun OM","year":"2024","journal-title":"J Clin Med"},{"issue":"4","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/humrep\/dev025","article-title":"Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence","volume":"30","author":"Ding D","year":"2015","journal-title":"Hum Reprod"},{"issue":"1","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fertnstert.2008.05.048","article-title":"The impact of peritoneal fluid from healthy women and from women with endometriosis on sperm DNA and its relationship to the sperm deformity index","volume":"92","author":"Mansour G","year":"2009","journal-title":"Fertil Steril"},{"issue":"9","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1177\/1933719116687658","article-title":"Peritoneal fluid from infertile women with minimal\/mild endometriosis compromises the meiotic spindle of metaphase II bovine oocytes: a pilot study","volume":"24","author":"Jianini BTGM","year":"2017","journal-title":"Reprod Sci"},{"issue":"8","key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/humrep\/deh324","article-title":"A combination of interleukin\u20106 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis","volume":"19","author":"Yoshida S","year":"2004","journal-title":"Hum Reprod"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:43:26Z","timestamp":1792478606000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":28,"alternative-id":["10.1002\/ijgo.71444"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71444","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijgo.71444"}}