{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:50:35Z","timestamp":1792230635936,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the antenatal natural history, prognostic factors, and perinatal outcomes of fetuses diagnosed with congenital pulmonary airway malformation (CPAM) in a resource\u2010limited tertiary fetal medicine setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective observational case series included 22 fetuses diagnosed with CPAM between 2018 and 2025 at a tertiary fetal medicine unit. Clinical, sonographic, and postnatal outcome data were obtained from electronic medical records and parental follow\u2010up. Lesions were categorized based on sonographic morphology, and serial congenital pulmonary airway malformation volume ratio (CVR) measurements were assessed to evaluate antenatal progression and prognostic correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 12\u2009058 anomaly scans conducted during the study period, 22 fetuses were diagnosed with CPAM, giving a prevalence of 0.18%. Microcystic CPAM was the predominant subtype (15\/22, 68%). Spontaneous regression occurred in 5\/22 (22.7%) cases, while 8\/22 (36.4%) demonstrated lesion plateauing, resulting in an overall regression\/plateau rate of 59.1%. A CVR &gt;1.6 was observed in two fetuses; one developed hydrops followed by intrauterine demise, while the other resulted in a live birth. Among the 22 antenatally diagnosed fetuses, outcomes included two terminations of pregnancy, one intrauterine demise and 19 live births. Immediate postnatal outcome data were available for 17\/19 neonates: 3\/17 (17.6%) had respiratory distress, while 14\/17 (82.4%) were asymptomatic at birth. Postnatal imaging was available in 17\/19 (89.5%) liveborn neonates and demonstrated persistent lesions in 9\/17 (52.9%) and apparent complete resolution in 7\/17 (41.2%). Overall, five neonates underwent lobectomy, all with favorable outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most antenatally diagnosed isolated CPAMs demonstrated a benign natural history with favorable perinatal outcomes. These findings support conservative management in carefully selected non\u2010hydropic fetuses; however, larger prospective studies with standardized postnatal imaging are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ijgo.71459","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:35:11Z","timestamp":1792229711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural history and perinatal outcomes of antenatally diagnosed\n                    <scp>CPAM<\/scp>\n                    in a resource\u2010limited setting"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2170-4092","authenticated-orcid":false,"given":"Shreya","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-8481","authenticated-orcid":false,"given":"Chanchal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4469-0782","authenticated-orcid":false,"given":"Vrunda","family":"Appannagari","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8661-4036","authenticated-orcid":false,"given":"Mohit","family":"Narayanaswamy","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8234-7055","authenticated-orcid":false,"given":"Jayasree","family":"Sundar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-6936","authenticated-orcid":false,"given":"Seema","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Birthright by Rainbow Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"221","article-title":"Congenital adenomatoid malformation of one lobe of a lung with general anasarca","volume":"48","author":"Ch'in KY","year":"1949","journal-title":"Arch Pathol (Chic)"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02347-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2026.162954"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_17_23"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20130"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.11.004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.03.039"},{"issue":"7","key":"e_1_2_10_10_1","first-page":"611","article-title":"Congenital thoracic malformations: antenatal course, postnatal management, and outcome","volume":"37","author":"Moroni F","year":"2017","journal-title":"Prenat Diagn"},{"key":"e_1_2_10_11_1","first-page":"818","article-title":"ISUOG practice guidelines: performance of fetal magnetic resonance imaging","volume":"56","author":"Prayer D","year":"2020","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2019.1613703"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2018.1520943"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.067"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2011.08.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-2909-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajps.ajps_116_22"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijgo.71459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijgo.71459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:35:12Z","timestamp":1792229712000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/ijgo.71459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,17]]},"references-count":16,"alternative-id":["10.1002\/ijgo.71459"],"URL":"https:\/\/doi.org\/10.1002\/ijgo.71459","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,17]]},"assertion":[{"value":"2026-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ijgo.71459"}}