{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T10:39:42Z","timestamp":1793875182333,"version":"4.6.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Psychol"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Early\u2010onset depression contributes significantly to the global health burden and has long\u2010term negative effects. This meta\u2010analysis collates and examines the effectiveness of family\u2010based interventions, where family members are involved in the treatment of depression in children and adolescents. A literature search was performed up to 8th March 2023. Randomised controlled trials of family\u2010based interventions were included for participants aged 3\u201318\u2009years with a diagnosis of major depressive disorder or dysthymia, according to the <jats:italic>Diagnostic and Statistical Manual of Mental Disorders<\/jats:italic> (5th ed.; DSM\u20105; American Psychiatric Association, 2013) or with a score above a cut\u2010off on a standardised self\u2010report depression measure. The overall effect size for treatment versus active control was <jats:italic>g<\/jats:italic>\u2009=\u20090.22 (95% confidence interval [CI]: \u22120.05\u20130.50) (nine studies; 659 participants), and for treatment versus non\u2010active control it was <jats:italic>g<\/jats:italic>\u2009=\u20090.46 (95% CI: \u22120.09\u20131.01) (four studies; 385 participants). Effect sizes were not statistically significant, and heterogeneity was high, ranging between <jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>\u2009=\u200964.3\u201381.1%. Subgroup analysis comparing attachment\u2010based family therapy with family therapy using other theoretical frameworks did not yield a significant difference between the two. The effects of family\u2010based therapies were larger than those in the comparison groups, but family\u2010based therapy did not demonstrate a significant treatment benefit compared to the controls. More randomised controlled trials are warranted, considering that evidence for other psychotherapies for depression in children and adolescents, indicates modest effects. Family\u2010based therapy may be an alternative for children and adolescents whose needs are not addressed by these treatments.<\/jats:p>","DOI":"10.1002\/ijop.12926","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T10:01:10Z","timestamp":1688637670000},"page":"499-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness of <scp>family\u2010based<\/scp> therapy for depressive symptoms in children and adolescents: A systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1002","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8799-8384","authenticated-orcid":false,"given":"Tanya","family":"van Aswegen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"},{"name":"Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences Vrije Universiteit Amsterdam &amp; Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Samartzi","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences Vrije Universiteit Amsterdam &amp; Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzette","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Rehabilitation Science, College of Health Sciences, QU\u00a0Health Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"van der Spek","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology Amsterdam Public Health Research Institute (APH), Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"de Vries","sequence":"additional","affiliation":[{"name":"Medical Library Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Seedat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine and Health Sciences Stellenbosch University  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke","family":"van Straten","sequence":"additional","affiliation":[{"name":"Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral and Movement Sciences Vrije Universiteit Amsterdam &amp; Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_3_1","volume-title":"APA clinical practice guideline for the treatment of depression across three age cohorts","author":"American Psychological Association","year":"2019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"Borenstein M.(2022). Comprehensive meta\u2010analysis software. In Systematic reviews in health research (pp. 535\u2010548). https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/9781119099369.ch27","DOI":"10.1002\/9781119099369.ch27"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-013-0377-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1997.01830210125017"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"32","article-title":"Family therapy with a depressed adolescent","volume":"6","author":"Broderick P.","year":"2009","journal-title":"Psychiatry (Edgmont (Pa: Township))"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmft.12217"},{"key":"e_1_2_6_9_1","unstructured":"Collaboration C. Higgins J. P. T. &Thomas J. T. A.\u2010T. T.(2021).Cochrane handbook for systematic reviews of interventions LK.https:\/\/vu.on.worldcat.org\/oclc\/1244252067(Version 6.). Version 6. Retrieved fromwww.training.cochrane.org\/handbook"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01372-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010021\u201001884\u20106"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.0164"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/famp.12241"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2018.10.006"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583\u2010200210000\u201000008"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-201002000-00006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2014.12.011"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2000.00455.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.084"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796015001158"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002317"},{"key":"e_1_2_6_22_1","volume-title":"Statistical methods for meta\u2010analysis","author":"Hedges L. V.","year":"2014"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006728"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39343.408449.80"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359104512455811"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)32279\u20107"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119085621.wbefs130"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.10179"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010020\u201001492\u2010w"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.4.365"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2011.02483.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18030321"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14616734.2017.1291696"},{"key":"e_1_2_6_36_1","unstructured":"National Institute for Health and Care Excellence. (2019). Depression in children and young people: identification andmanagement [NICE Guideline No. 134].http:\/\/www.nice.org.uk\/guidance\/ng134"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2018.12.008"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_6_39_1","first-page":"27","article-title":"Attachment and emotion in middle childhood and adolescence","volume":"24","author":"Parrigon K. S.","year":"2015","journal-title":"Psychological Topics"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.12.003"},{"issue":"4","key":"e_1_2_6_41_1","first-page":"951","article-title":"Scales of potential use in the psychopharmacologic treatment of depressed children and adolescents","volume":"21","author":"Petti T. A.","year":"1985","journal-title":"Psychopharmacology Bulletin"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10802-017-0292-7"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2009.11.1\/urao"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.02.005"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1545\u20105300.2002.41305.x"},{"key":"e_1_2_6_46_1","unstructured":"RStudio Team. (2020). RStudio: integrated development for R. RStudio PBC.http:\/\/www.rstudio.com\/"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10567\u2010005\u20106666\u20103"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10567\u2010019\u201000299\u20109"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100355(199023)11:3<218::AID\u2010IMHJ2280110304>3.0.CO;2\u20101"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2017.03.018"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-006-0584-x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.4103\/psychiatry.IndianJPsychiatry_770_19"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583\u2010200010000\u201000006"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13034\u2010021\u201000361\u2010x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.132.1.132"},{"key":"e_1_2_6_57_1","volume-title":"The age of onset of unipolar depression BT \u2010 age of onset of mental disorders: Etiopathogenetic and treatment implications","author":"Yalin N.","year":"2019"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20217"}],"container-title":["International Journal of Psychology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijop.12926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T22:04:55Z","timestamp":1700604295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijop.12926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/ijop.12926"],"URL":"https:\/\/doi.org\/10.1002\/ijop.12926","archive":["Portico"],"relation":{},"ISSN":["0020-7594","1464-066X"],"issn-type":[{"value":"0020-7594","type":"print"},{"value":"1464-066X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,6]]},"assertion":[{"value":"2022-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}