{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:33:24Z","timestamp":1740180804072,"version":"3.37.3"},"reference-count":6,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T00:00:00Z","timestamp":1538265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Methotrexate has been reported to increase the risk of lymphoproliferative disorders. We report a rare case who was clinically diagnosed with methotrexate\u2010associated lymphoproliferative disorders of the kidney.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 77\u2010year\u2010old patient with rheumatoid arthritis had taken low\u2010dose methotrexate for 13\u00a0years. The patient developed left renal mass 3\u00a0cm in size and multiple pulmonary nodules. Initially, renal malignant tumor with lung metastases was considered and the renal biopsy was planned. However, under possible diagnosis of methotrexate\u2010related lymphoproliferative disorder, we withdrew methotrexate treatment at first and then observed spontaneous regression of the tumorous lesions of the kidney and lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although methotrexate\u2010related lymphoproliferative disorder in kidneys is very rare, our case advocates the importance of a relevant differential diagnosis of methotrexate\u2010related lymphoproliferative disorder under the setting of long\u2010term treatment of methotrexate for rheumatoid arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12020","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T23:38:11Z","timestamp":1538350691000},"page":"16-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous regression of a renal mass and multiple lung nodules after methotrexate cessation"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-3954","authenticated-orcid":false,"given":"Takuya","family":"Iwaki","sequence":"first","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama Medical Center Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama Medical Center Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Urology Kyorin University School of Medicine Mitaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uran","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama Medical Center Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama Medical Center Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Azuma","sequence":"additional","affiliation":[{"name":"Department of Urology Tokyo Metropolitan Tama Medical Center Fuchu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Tokyo Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,30]]},"reference":[{"volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","year":"2017","author":"Swerdlow SH","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12116"},{"key":"e_1_2_7_4_1","first-page":"322","article-title":"Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication","volume":"34","author":"Hoshida Y","year":"2007","journal-title":"J. Rheumatol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"e_1_2_7_6_1","first-page":"1741","article-title":"Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate","volume":"18","author":"Ellman MH","year":"1991","journal-title":"J. Rheumatol."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130270"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fiju5.12020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12020","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:22:22Z","timestamp":1694755342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,30]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/iju5.12020"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12020","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"type":"print","value":"2577-171X"},{"type":"electronic","value":"2577-171X"}],"subject":[],"published":{"date-parts":[[2018,9,30]]},"assertion":[{"value":"2018-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}