{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:17:24Z","timestamp":1784297844121,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We herein present a case of malignant melanoma of the male urethra with an increased serum 5\u2010<jats:italic>S<\/jats:italic>\u2010cysteinyldopa concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 77\u2010year\u2010old man visited our hospital complaining dysuria and a dark brown mass protruding from the external urethral meatus. His serum 5\u2010<jats:italic>S<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">cysteinyldopa<\/jats:styled-content> concentration was elevated beyond the upper limit of the reference range. Biopsy of the tumor was performed, and the histological diagnosis was malignant melanoma. He underwent total penectomy, and the serum 5\u2010<jats:italic>S<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">cysteinyldopa<\/jats:styled-content> concentration was normalized. He remained alive without evidence of locoregional recurrence or distant metastases for 6\u00a0months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malignant melanoma of the male urethra is uncommon. The prognosis is favorable if it is detected in its early stages. This case report suggests that measurement of the serum concentration of 5\u2010<jats:italic>S<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">cysteinyldopa<\/jats:styled-content>, a melanin metabolite, is useful for early diagnosis of male urethral melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12086","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T04:24:39Z","timestamp":1560313479000},"page":"215-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Malignant melanoma of the male urethra with increased 5\u2010<i>S<\/i>\u2010cysteinyldopa: A case report"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8636-4491","authenticated-orcid":false,"given":"Yusuke","family":"Aoki","sequence":"first","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"},{"name":"Department of Urology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naotaka","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Department of Urology Saitama Cancer Center Ina\u2010machi Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-006-9086-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328334c39a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)41490-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000279774"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4065\/72.4.362"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90120-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-340"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.039"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(91)80268-C"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200006000-00003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03649.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199606000-00001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199706000-00009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199702000-00009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015559850135797"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70206-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000159207.91737.53"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65169-5"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08260-3"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"}],"container-title":["IJU Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/iju5.12086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/iju5.12086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T11:52:54Z","timestamp":1694260374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/iju5.12086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/iju5.12086"],"URL":"https:\/\/doi.org\/10.1002\/iju5.12086","archive":["Portico"],"relation":{},"ISSN":["2577-171X","2577-171X"],"issn-type":[{"value":"2577-171X","type":"print"},{"value":"2577-171X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"assertion":[{"value":"2019-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}