{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:13:59Z","timestamp":1747149239066,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Several types of cancers are reported to induce secondary immune thrombocytopenia resembling immune thrombocytopenic purpura\u2010like syndrome. However, renal cell carcinoma\u2010induced immune thrombocytopenic purpura is an extremely rare phenomenon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 73\u2010year\u2010old male with right renal tumor and multiple enlarged lymph nodes presented severe thrombocytopenia, without bone or hepatic metastasis. Although platelet transfusion and high\u2010dose immunoglobulin treatment were refractory, surgical resection of the tumor and lymph nodes promptly improved thrombocytopenia. After recurrence, he presented thrombocytopenia again. Tyrosine kinase inhibitor treatment was ceased due to uncontrollable hemorrhagic gastric ulcer. The patient eventually died of cancer 4\u00a0months after surgery. Flow cytometry analysis revealed the presence of integrin glycoprotein <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>b\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>a, which is a fibronectin\/fibrinogen receptor on platelets and as an antigen in immune thrombocytopenic purpura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To the best of our knowledge, this is the first reported case of renal cell carcinoma\u2010induced immune thrombocytopenic purpura that demonstrates the presence of platelet\u2010autoantibody glycoprotein <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>b\/<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>a.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12088","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T13:46:44Z","timestamp":1564753604000},"page":"250-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Secondary immune thrombocytopenic purpura with renal cell carcinoma"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-3483","authenticated-orcid":false,"given":"Shigeaki","family":"Nakazawa","sequence":"first","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"},{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"},{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"},{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norichika","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"},{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidefumi","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Urology Hyogo Prefectural Nishinomiya Hospital Nishinomiya Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Nonomura","sequence":"additional","affiliation":[{"name":"Department of Urology Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-409995"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010501"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225597"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20116"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(84)90049-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.5.671"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65314-1"},{"key":"e_1_2_6_9_1","first-page":"889","article-title":"Double lung cancer combined with idiopathic thrombocytopenic purpura. A case report","volume":"40","author":"Nonami Y","year":"1999","journal-title":"J. Cardiovasc. 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