{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:48:10Z","timestamp":1772088490386,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["IJU Case Reports"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The safety and efficacy of combination therapy comprising immune checkpoint inhibitors and cancer\u2010specific peptide vaccines have not yet been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 71\u2010year\u2010old female metastatic renal cell carcinoma patient with multiple lung and pleural metastases. She had been treated with interferon alpha, sunitinib, axitinib, and pazopanib sequentially, but no clinical efficacy was observed. She participated in a clinical trial using cancer\u2010specific peptide vaccine therapy. Initially no antitumor effect was observed, and vaccine therapy was ceased after two courses. But 3\u00a0months after the start of nivolumab, remarkable tumor shrinkage was observed at all metastatic sites, which resulted in almost complete response at 6\u00a0months. At 10\u00a0months, nivolumab was stopped due to cellulitis at the peptide vaccine inoculation site. Intriguingly, even after nivolumab discontinuation, complete response was maintained for more than 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We experienced a remarkable antitumor effect by nivolumab in a patient who was previously treated with vaccine therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/iju5.12139","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T01:14:50Z","timestamp":1578618890000},"page":"44-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Remarkable antitumor effect of nivolumab in a patient with metastatic renal cell carcinoma previously treated with a peptide\u2010based vaccine"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6972-8065","authenticated-orcid":false,"given":"Ryoma","family":"Kurahashi","sequence":"first","affiliation":[{"name":"Department of Urology Faculty of 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